An efficient virus-induced gene silencing

Gene-Modifying Applied sciences Paired With Viral Vectors for Translational Analysis Into Neurodegenerative Ailments 

Ailments of the central nervous system (CNS) have traditionally been among the many most troublesome to deal with utilizing typical pharmacological approaches. This is because of a confluence of things, together with the restricted regenerative capability and general complexity of the mind, issues related to repeated drug administration, and difficulties delivering medication throughout the blood-brain barrier (BBB). Viral-mediated gene switch represents a pretty various for the supply of therapeutic cargo to the nervous system. Crucially, it often requires solely a single injection, whether or not that be a gene substitute technique for an inherited dysfunction or the supply of a genome- or epigenome-modifying assemble for remedy of CNS illnesses and issues.

It’s thus comprehensible that appreciable effort has been put in direction of the event of improved vector techniques for gene switch into the CNS. Totally different viral vectors are in fact tailor-made to their particular purposes, however they typically ought to share a number of key properties. The best viral vector incorporates a high-packaging capability, environment friendly gene switch paired with sturdy and sustained expression, lack of oncogenicity, toxicity and pathogenicity, and scalable manufacturing for medical purposes. On this evaluation, we’ll dedicate consideration to viral vectors derived from human immunodeficiency virus sort 1 (lentiviral vectors; LVs) and adeno-associated virus (AAVs).

The excessive curiosity in these viral supply techniques vectors is because of: (i) sturdy supply and long-lasting expression; (ii) environment friendly transduction into postmitotic cells, together with the mind; (iii) low immunogenicity and toxicity; and (iv) compatibility with superior manufacturing strategies. Right here, we’ll define primary points of LV and AAV biology, notably specializing in approaches and strategies aiming to reinforce viral security.

We may also allocate a good portion of this evaluation to the event and use of LVs and AAVs for supply into the CNS, with a concentrate on the genome and epigenome-editing instruments primarily based on clustered repeatedly interspaced quick palindromic repeats/CRISPR-associated protein 9 (CRISPR/Cas 9) and the event of novel methods for the remedy of neurodegenerative illnesses (NDDs).

Polyclonal Goat anti-GST α-form
GST-ANTI-1	Detroit R&D	50 uL	EUR 280

Recombinant Human Galectin-1 Protein
PROTP09382-1	BosterBio	50ug	EUR 317
Description: Lectins, of either plant or animal origin, are carbohydrate binding proteins that interact with glycoprotein and glycolipids on the surface of animal cells. The Galectins are lectins that recognize and interact with β-galactoside moieties. Galectin-1 is an animal lectin that has been shown to interact with CD3, CD4, and CD45. It induces apoptosis of activated T-cells and T-leukemia cell lines and inhibits the protein phosphatase activity of CD45. Recombinant human Galectin-1 is a 14.5 kDa protein containing 134 amino acid residues.

Anti-Galectin-3 Monoclonal Antibody
M00621-1	BosterBio	100ul	EUR 397
Description: Mouse Monoclonal Galectin-3 Antibody. Validated in IF, IHC, WB and tested in Human, Mouse, Rat.

anti-Galectin 1
YF-PA12945	Abfrontier	100 ug	EUR 403
Description: Rabbit polyclonal to Galectin 1

Rabbit Polyclonal antibody Anti-CRBN
Anti-CRBN	ImmunoStep	50 µg	EUR 349

Anti-Galectin 1 Antibody
A00470-2	BosterBio	100ug/vial	EUR 294

anti- Galectin-1 antibody
FNab03314	FN Test	100µg	EUR 505.25
Recommended dilution: WB: 1:500-1:1000 IHC: 1:20-1:200 Immunogen: lectin, galactoside-binding, soluble, 1 Uniprot ID: P09382 Gene ID: 3956 Research Area: Cell Division and Proliferation, Cardiovascular, Signal Transduction
Description: Antibody raised against Galectin-1

anti- Galectin-1 antibody
FNab03315	FN Test	100µg	EUR 548.75
Recommended dilution: WB: 1:500-1:2000 IHC: 1:20-1:200 Immunogen: lectin, galactoside-binding, soluble, 1 Uniprot ID: P09382 Gene ID: 3956 Research Area: Cell Division and Proliferation, Cardiovascular, Signal Transduction
Description: Antibody raised against Galectin-1

Anti-Galectin-1 antibody
PAab03314	Lifescience Market	100 ug	EUR 355

Anti-Galectin-1 antibody
STJ93201	St John's Laboratory	200 µl	EUR 197
Description: Rabbit polyclonal to Galectin-1.

Anti-Galectin-1 antibody
STJ98716	St John's Laboratory	200 µl	EUR 197
Description: Rabbit polyclonal to Galectin-1.

Anti-Galectin 1 (1A8)
YF-MA13984	Abfrontier	100 ug	EUR 363
Description: Mouse monoclonal to Galectin 1

Anti-Galectin 1/Lgals1 Antibody
A00470	BosterBio	100ug/vial	EUR 334

Anti-Galectin 1 Biotinylated Antibody
A00470-Biotin	BosterBio	50ug/vial	EUR 294

Anti-Galectin 1/LGALS1 Antibody
PA1422	BosterBio	100ug/vial	EUR 334

anti-Galectin 1 (1E8-1B2)
LF-MA10174	Abfrontier	100 ug	EUR 363
Description: Mouse monoclonal to Galectin 1

Anti-Galectin 1/LGALS1 Antibody
PB9240	BosterBio	100ug/vial	EUR 334

Anti-galectin-1 (mouse) antibody
STJ72519	St John's Laboratory	100 µg	EUR 359

Anti-Galectin-13 (GAL13) / Placental Protein 13 (PP13) Monoclonal Antibody
M08143-1	BosterBio	100ug/vial	EUR 397
Description: Mouse Monoclonal Galectin-13 (GAL13) / Placental Protein 13 (PP13) Antibody. Validated in IHC and tested in Human.

anti-Galectin 3
YF-PA12946	Abfrontier	50 ug	EUR 363
Description: Mouse polyclonal to Galectin 3

anti-Galectin 3
YF-PA12947	Abfrontier	100 ul	EUR 403
Description: Rabbit polyclonal to Galectin 3

anti-Galectin 3
YF-PA12948	Abfrontier	100 ug	EUR 403
Description: Rabbit polyclonal to Galectin 3

anti-Galectin 8
YF-PA12951	Abfrontier	50 ul	EUR 363
Description: Mouse polyclonal to Galectin 8

anti-Galectin 13
YF-PA18585	Abfrontier	50 ug	EUR 363
Description: Mouse polyclonal to Galectin 13

anti-Galectin 3
YF-PA24079	Abfrontier	50 ul	EUR 334
Description: Mouse polyclonal to Galectin 3

anti-galectin 9
YF-PA24081	Abfrontier	50 ul	EUR 334
Description: Mouse polyclonal to galectin 9

Polyclonal Goat anti-GST μ-form
GST-ANTI-2	Detroit R&D	50 uL	EUR 280

Polyclonal Goat anti-GST p-form
GST-ANTI-3	Detroit R&D	50 uL	EUR 280

LGALS7 Human, Galectin-7 Human Recombinant Protein, His Tag
PROTP47929-1	BosterBio	Regular: 20ug	EUR 317
Description: Galectin-7 Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 156 amino acids (1-136 a.a.) and having a molecular mass of 17.2kDa. ;The Galectin-7 is purified by proprietary chromatographic techniques.

LGALS8 Human, Galectin-8 Human Recombinant Protein, His Tag
PROTO00214-1	BosterBio	Regular: 10ug	EUR 317
Description: LGALS8 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 337 amino acids (1-317 a.a.) and having a molecular mass of 37.9 kDa. The LGALS8 is fused to a 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.

LGALS3 Human, Galectin-3 Human Recombinant Protein, His Tag
PROTP17931-1	BosterBio	Regular: 25ug	EUR 317
Description: LGALS3 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 270 amino acids (1-250 a.a.) and having a molecular mass of 28.3 kDa._x000D_ The LGALS3 is fused to a 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques. _x000D_

Anti-human Galectin-3 antibody
STJ15100163	St John's Laboratory	250 µg	EUR 336
Description: This monoclonal antibody is for studies of antigen expression in cells and tissue sections using immunocytochemistry and immunoprecipitation

Human Galectin-3 (Gal-3) AssayMax ELISA Kit
EG3311-1	AssayPro	96 Well Plate	EUR 477

Human Galectin-4 (Gal-4) AssayMax ELISA Kit
EG3312-1	AssayPro	96 Well Plate	EUR 477

Recombinant Human Galectin-1
7-00427	CHI Scientific	10µg	Ask for price

Recombinant Human Galectin-1
7-00428	CHI Scientific	50µg	Ask for price

Recombinant Human Galectin-1
7-00429	CHI Scientific	1mg	Ask for price

Galectin-1, human recombinant
4648-10	Biovision		EUR 142

Galectin-1, human recombinant
4648-1000	Biovision		EUR 1648

Galectin-1, human recombinant
4648-50	Biovision		EUR 262

Human Galectin-1 (LGALS1)
1-CSB-EP012882HU	Cusabio	EUR 380.00 EUR 214.00 EUR 1309.00 EUR 560.00 EUR 873.00 EUR 262.00	100ug 10ug 1MG 200ug 500ug 50ug
MW: 30.6 kDa Buffer composition: Tris-based buffer with 50% glycerol.
Description: Recombinant Human Galectin-1(LGALS1) expressed in E.coli

Human Galectin-1 (LGALS1)
1-CSB-EP012882HUb1	Cusabio	EUR 380.00 EUR 214.00 EUR 1309.00 EUR 560.00 EUR 873.00 EUR 262.00	100ug 10ug 1MG 200ug 500ug 50ug
MW: 19.6 kDa Buffer composition: Tris-based buffer with 50% glycerol.
Description: Recombinant Human Galectin-1(LGALS1) expressed in E.coli

Human Galectin 1 Protein
20-abx066725	Abbexa	EUR 620.00 EUR 272.00 EUR 1859.00 EUR 732.00 EUR 453.00	100 ug 10 ug 1 mg 200 ug 50 ug
Shipped within 5-7 working days.

Anti-Galectin-9 Antibody
A03415	BosterBio	100ul	EUR 397
Description: Rabbit Polyclonal Antibody for Galectin-9 Antibody (LGALS9) detection.tested for WB in Human, Mouse, Rat.

anti- Galectin 2 antibody
FNab03310	FN Test	100µg	EUR 585
Immunogen: lectin, galactoside-binding, soluble, 2 Uniprot ID: P05162 Research Area: Immunology, Signal Transduction, Cell Division and Proliferation
Description: Antibody raised against Galectin 2

anti- Galectin 4 antibody
FNab03311	FN Test	100µg	EUR 505.25
Recommended dilution: WB: 1:500-1:1000 IHC: 1:20-1:200 IF: 1:10-1:100 Immunogen: lectin, galactoside-binding, soluble, 4 Uniprot ID: P56470 Research Area: Immunology, Signal Transduction, Cell Division and Proliferation
Description: Antibody raised against Galectin 4

anti- Galectin 8 antibody
FNab03312	FN Test	100µg	EUR 505.25
Immunogen: lectin, galactoside-binding, soluble, 8 Uniprot ID: O00214 Research Area: Immunology, Signal Transduction, Cell Division and Proliferation
Description: Antibody raised against Galectin 8

anti- Galectin 9 antibody
FNab03313	FN Test	100µg	EUR 505.25
Immunogen: lectin, galactoside-binding, soluble, 9 Uniprot ID: O00182 Research Area: Immunology, Signal Transduction, Cell Division and Proliferation
Description: Antibody raised against Galectin 9

anti- Galectin-3 antibody
FNab03316	FN Test	100µg	EUR 505.25
Recommended dilution: WB: 1:500-1:5000 IP: 1:200-1:2000 IHC: 1:20-1:200 IF: 1:10-1:100 Immunogen: lectin, galactoside-binding, soluble, 3 Uniprot ID: P17931 Research Area: Cardiovascular, Cancer, Immunology, Neuroscience, Cell Division and Prolife Show more
Description: Antibody raised against Galectin-3

anti- Galectin-3 antibody
FNab03317	FN Test	100µg	EUR 548.75
Recommended dilution: WB: 1:1000-1:5000 IHC: 1:50-1:200 IF: 1:20-1:200 Immunogen: lectin, galactoside-binding, soluble, 3 Uniprot ID: P17931 Research Area: Cardiovascular, Cancer, Immunology, Neuroscience, Cell Division and Proliferation
Description: Antibody raised against Galectin-3

anti- Galectin-7 antibody
FNab03318	FN Test	100µg	EUR 505.25
Recommended dilution: WB: 1:1000-1:4000 IHC: 1:20-1:200 Immunogen: lectin, galactoside-binding, soluble, 7B Uniprot ID: P47929 Gene ID: 653499 Research Area: Immunology, Cancer, Immunology, Neuroscience, Cell Division and Proliferation
Description: Antibody raised against Galectin-7

anti-Galectin-3 (6G2)
LF-MA20336	Abfrontier	100 ug	EUR 354
Description: Mouse monoclonal to Galectin-3

Anti-Galectin 2 antibody
PAab03310	Lifescience Market	100 ug	EUR 412

Anti-Galectin 4 antibody
PAab03311	Lifescience Market	100 ug	EUR 355

Anti-Galectin 8 antibody
PAab03312	Lifescience Market	100 ug	EUR 355

Anti-Galectin 9 antibody
PAab03313	Lifescience Market	100 ug	EUR 355

Anti-Galectin-3 antibody
PAab03316	Lifescience Market	100 ug	EUR 355

Anti-Galectin-7 antibody
PAab03318	Lifescience Market	100 ug	EUR 355

Anti-Galectin-3 antibody
STJ16100369	St John's Laboratory	1 mL	EUR 1047

Anti-Galectin-3 antibody
STJ16100782	St John's Laboratory	100 µg	EUR 720

Anti-Galectin-2 antibody
STJ93202	St John's Laboratory	200 µl	EUR 197
Description: Rabbit polyclonal to Galectin-2.

Anti-Galectin-4 antibody
STJ93203	St John's Laboratory	200 µl	EUR 197
Description: Rabbit polyclonal to Galectin-4.

Anti-Galectin-7 antibody
STJ93204	St John's Laboratory	200 µl	EUR 197
Description: Rabbit polyclonal to Galectin-7.

Anti-Galectin-8 antibody
STJ93205	St John's Laboratory	200 µl	EUR 197
Description: Rabbit polyclonal to Galectin-8.

Anti-Galectin-9 antibody
STJ93206	St John's Laboratory	200 µl	EUR 197
Description: Rabbit polyclonal to Galectin-9.

Anti-Galectin 3 antibody
STJ73098	St John's Laboratory	100 µg	EUR 359

Anti-Galectin-3 antibody
STJ180106	St John's Laboratory	0.1 ml	EUR 212

Anti-Galectin 3 antibody
STJ190057	St John's Laboratory	200 µl	EUR 197
Description: Unconjugated Mouse monoclonal to Galectin 3 (AS1A24)

Anti-Galectin-3 antibody
STJ96945	St John's Laboratory	200 µl	EUR 197
Description: Galectin-3 is a protein encoded by the LGALS3 gene which is approximately 26,1 kDa. Galectin-3 is localised to the cytoplasm and nucleus. It is involved in NF-kappaB signalling, advanced glycosylation end product receptor signalling and cell adhesion. It is a galactose-specific lectin which binds IgE and may mediate the stimulation by CSPG4 of endothelial cells migration along with the alpha-3, beta-1 integrin. It is characterized by an N-terminal proline-rich tandem repeat domain and a single C-terminal carbohydrate recognition domain. Galectin-3 is expressed mainly in the colonic epithelium and is also abundantly expressed in activated macrophages. Mutations in the LGALS3 gene may result in follicular adenoma and thyroid cancer. STJ96945 was developed from clone 6G2 and was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. This antibody detects endogenous galectin-3 proteins.

Anti-Galectin-3 antibody
STJ97549	St John's Laboratory	200 µl	EUR 197
Description: Mouse monoclonal to Galectin-3 (6B8).

Anti-Galectin-3 antibody
STJ97550	St John's Laboratory	200 µl	EUR 197
Description: Mouse monoclonal to Galectin-3 (8D7).

Anti-Galectin-3 antibody
STJ97551	St John's Laboratory	200 µl	EUR 197
Description: Mouse monoclonal to Galectin-3 (5D9).

Anti-Galectin-3 antibody
STJ97601	St John's Laboratory	200 µl	EUR 197
Description: Mouse monoclonal to Galectin-3 (2F9).

Anti-Galectin-3 antibody
STJ97604	St John's Laboratory	200 µl	EUR 197
Description: Mouse monoclonal to Galectin-3 (16E6).

Anti-Galectin-3 antibody
STJ97605	St John's Laboratory	200 µl	EUR 197
Description: Mouse monoclonal to Galectin-3 (1H4).

Anti-Galectin-3 antibody
STJ97715	St John's Laboratory	200 µl	EUR 197
Description: Mouse monoclonal to Galectin-3.

Anti-Galectin 8 (3E5)
YF-MA13986	Abfrontier	100 ug	EUR 363
Description: Mouse monoclonal to Galectin 8

Anti-galectin-1 (mouse) (aa100-112) antibody
STJ72520	St John's Laboratory	100 µg	EUR 359

Anti Human Galectin-3 Polyclonal Antibody
KH040	Sceti		EUR 649
Description: The Anti Human Galectin-3 Polyclonal Antibody is available in Europe and for worldwide shipping via Gentaur.

Anti-Galectin-1 / Human Placental Lactogen (hPL) Monoclonal Antibody
M00470	BosterBio	100ug/vial	EUR 397
Description: Mouse Monoclonal Galectin-1 / Human Placental Lactogen (hPL) Antibody. Validated in IHC and tested in Human.

Galectin 1 protein
30R-1385	Fitzgerald	100 ug	EUR 224
Description: Purified recombinant Human Galectin 1 protein

Galectin 1 protein
30R-2371	Fitzgerald	50 ug	EUR 353
Description: Purified recombinant Human Galectin 1 protein

Galectin 1 protein
30R-AG003	Fitzgerald	10 ug	EUR 133
Description: Purified recombinant Human Galectin 1 protein

Galectin 1 antibody
70R-11939	Fitzgerald	100 ug	EUR 403
Description: Rabbit polyclonal Galectin 1 antibody

Galectin 1 antibody
70R-13963	Fitzgerald	100 ug	EUR 322
Description: Affinity purified Rabbit polyclonal Galectin 1 antibody

Galectin-1 Antibody
3596-100	Biovision		EUR 316

Galectin-1 Antibody
3596-30T	Biovision		EUR 146

Galectin 1 Antibody
49673-100ul	SAB	100ul	EUR 333

Galectin 1 Antibody
49673-50ul	SAB	50ul	EUR 239

Galectin 1 antibody
70R-GR002	Fitzgerald	100 ug	EUR 476
Description: Affinity purified Rabbit polyclonal Galectin 1 antibody

Galectin 1 antibody
70R-49997	Fitzgerald	100 ul	EUR 244
Description: Purified Polyclonal Galectin 1 antibody

Galectin-1 Protein
20-abx261634	Abbexa	EUR 3418.00 EUR 328.00 EUR 230.00	1 mg 20 ug 5 ug
Shipped within 5-10 working days.

Galectin-1 Protein
20-abx263505	Abbexa	EUR 230.00 EUR 1790.00 EUR 328.00	10 ug 1 mg 50 ug
Shipped within 5-10 working days.

rHu Galectin-1
AK8281-0010	Akron Biotech	10µg	Ask for price

rHu Galectin-1
AK8281-0050	Akron Biotech	50µg	Ask for price

rHu Galectin-1
AK8281-0100	Akron Biotech	100µg	Ask for price

rHu Galectin-1
AK8281-1000	Akron Biotech	1mg	Ask for price

An environment friendly virus-induced gene silencing (VIGS) system for purposeful genomics in Brassicas utilizing a cabbage leaf curl virus (CaLCuV)-based vector 

CaLCuV-based VIGS successfully works in cabbage and contributes to environment friendly purposeful genomics analysis in Brassica crop species. Virus-induced gene silencing (VIGS), a posttranscriptional gene silencing methodology, is an efficient approach for analysing the capabilities of genes in vegetation. Nevertheless, no VIGS vectors have been obtainable for Brassica oleracea till now. Right here, tobacco rattle virus (TRV), pTYs and cabbage leaf curl virus (CaLCuV) gene-silencing vectors (PCVA/PCVB) had been chosen to enhance the VIGS system in cabbage utilizing the phytoene desaturase (PDS) gene as an environment friendly visible indicator of VIGS. We efficiently silenced the expression of PDS and noticed photobleaching phenomena in cabbage in response to pTYs and CaLCuV, with the latter being simpler to function and cheaper.

The parameters doubtlessly affecting the silencing effectivity of VIGS by CaLCuV in cabbage, together with the focusing on fragment technique, inoculation methodology and incubation temperature, had been then in contrast. The optimized CaLCuV-based VIGS system includes the next: an roughly 500 bp insert sequence, an Agrobacterium OD₆₀₀ of 1.0, use of the vacuum osmosis methodology utilized on the bud stage, and an incubation temperature of 22 °C.

Utilizing these parameters, we achieved a steady silencing effectivity of 65%. To additional take a look at the effectiveness of the system, we chosen the Mg-chelatase H subunit (ChlH) gene in cabbage and knocked down its expression, and we noticed yellow leaves, as anticipated. We efficiently utilized the CaLCuV-based VIGS system to 2 different consultant Brassica crop species, B. rapa and B. nigra, and thus expanded the appliance scope of this method. Our VIGS system described right here will contribute to environment friendly purposeful genomics analysis in Brassica crop species.

Ocular Gene Remedy with Adeno-associated Virus Vectors: Present Outlook for Sufferers and Researchers 

On this “Perspective”, we talk about ocular gene remedy – the affected person’s perspective, the assorted methods of gene substitute and gene modifying, the place of adeno-associated virus vectors, routes of supply to the attention and the remaining query – “why does immunity proceed to restrict efficacy?” Via the coordinated efforts of sufferers, researchers, granting companies and business, and after a few years of pre-clinical research, biochemical, mobile, and animal fashions, we’re seeing medical trials emerge for a lot of beforehand untreatable heritable ocular issues.

The pathway to therapies has been led by the profitable remedy of the RPE65 type of Leber congenital amaurosis with LUXTURNA TM . In some instances, immune reactions to the vectors proceed to happen, limiting efficacy.

The underlying mechanisms of irritation require additional research, and new vectors have to be designed that restrict the triggers of immunity. Researchers finding out ocular gene therapies and clinicians enrolling sufferers in medical trials should acknowledge the present limitations of those therapies to correctly handle expectations and keep away from disappointment, however we imagine that gene therapies are effectively on their solution to profitable, widespread utilization to deal with heritable ocular issues.

EBV-miR-BART12 accelerates migration and invasion in EBV-associated most cancers cells by focusing on tubulin polymerization-promoting protein 1

Epstein-Barr virus (EBV) an infection results in cancers with an epithelial origin, akin to nasopharyngeal most cancers and gastric most cancers, in addition to a number of blood cell-based malignant tumors, akin to lymphoma. Apparently, EBV can also be the primary virus discovered to hold genes encoding miRNAs. EBV encodes 25 kinds of pre-miRNAs that are lastly processed into 44 mature miRNAs. Most EBV-encoded miRNAs had been discovered to be concerned within the prevalence and improvement of EBV-related tumors.

Nevertheless, the perform of EBV-miR-BART12 stays unclear. The findings of the present research revealed that EBV-miR-BART12 binds to the three’UTR area of Tubulin Polymerization-Selling Protein 1 (TPPP1) mRNA and downregulates TPPP1, thereby selling the invasion and migration of EBV-related cancers, akin to nasopharyngeal most cancers and gastric most cancers.

The mechanism underlying this course of was discovered to be the inhibition of TPPP1 by EBV-miRNA-BART12, which, in flip, inhibits the acetylation of α-tubulin, and promotes the dynamic meeting of microtubules, remodels the cytoskeleton, and enhances the acetylation of β-catenin. β-catenin prompts epithelial to mesenchymal transition (EMT).

These two processes synergistically promote the invasion and metastasis of tumor cells. To one of the best of our information, that is the primary research to disclose the function of EBV-miRNA-BART12 within the improvement of EBV-related tumors in addition to the mechanism underlying this course of, and suggests potential targets and methods for the remedy of EBV-related tumors.

Anti-Podoplanin antibody
PAab06599	Lifescience Market	100 ug	EUR 412

Anti-Podoplanin antibody
STJ180226	St John's Laboratory	0.1 ml	EUR 266

Anti-Podoplanin antibody
STJ180283	St John's Laboratory	0.1 ml	EUR 223

Rabbit Polyclonal antibody Anti-CRBN
Anti-CRBN	ImmunoStep	50 µg	EUR 349

Podoplanin
MO47016	Neuromics	100 ul	EUR 349

Anti-Podoplanin/gp36/PDPN Antibody
A01124	BosterBio	100ug/vial	EUR 294

Anti-Podoplanin/gp36/PDPN Antibody
PA1411	BosterBio	100ug/vial	EUR 294

Anti-Podoplanin/gp36/PDPN Antibody
PA1674	BosterBio	100ug/vial	EUR 294

Anti-Podoplanin/gp36/PDPN Antibody
PA1675	BosterBio	100ug/vial	EUR 294

Anti-Podoplanin Rabbit Monoclonal Antibody
M01124-1	BosterBio	100ug/vial	EUR 397
Description: Rabbit Monoclonal Podoplanin Antibody. Validated in WB and tested in Human, Mouse, Rat.

Anti-Podoplanin Rabbit Monoclonal Antibody
M01124-2	BosterBio	100ug/vial	EUR 397
Description: Rabbit Monoclonal Podoplanin Antibody. Validated in WB and tested in Human.

Anti-D2-40 Podoplanin antibody
STJ16100360	St John's Laboratory	1 mL	EUR 1235

Anti-D2-40/Podoplanin antibody
STJ190048	St John's Laboratory	200 µl	EUR 197
Description: Unconjugated Mouse monoclonal to D2-40/Podoplanin (7D1)

Mouse Podoplanin ELISA kit
E03P0082-192T	B-Gene	192 tests	EUR 1270
Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT Show more
Description: A sandwich ELISA for quantitative measurement of Mouse Podoplanin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Podoplanin ELISA kit
E03P0082-48	B-Gene	1 plate of 48 wells	EUR 520
Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT Show more
Description: A sandwich ELISA for quantitative measurement of Mouse Podoplanin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Podoplanin ELISA kit
E03P0082-96	B-Gene	1 plate of 96 wells	EUR 685
Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT Show more
Description: A sandwich ELISA for quantitative measurement of Mouse Podoplanin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Podoplanin (PDPN) Protein
20-abx650139	Abbexa	EUR 648.00 EUR 272.00 EUR 1943.00 EUR 759.00 EUR 467.00	100 ug 10 ug 1 mg 200 ug 50 ug
Shipped within 5-7 working days.

Mouse Anti-Human Podoplanin monoclonal antibody, clone JID761
CABT-L2919-100uL500uL	Creative Diagnostics	100 uL, 500 uL	EUR 502

Podoplanin antibody
70R-11540	Fitzgerald	100 ug	EUR 527
Description: Rabbit polyclonal Podoplanin antibody

Podoplanin antibody
70R-13952	Fitzgerald	100 ug	EUR 305
Description: Affinity purified Rabbit polyclonal Podoplanin antibody

Podoplanin antibody
10R-P133a	Fitzgerald	100 ug	EUR 507
Description: Mouse monoclonal Podoplanin antibody

Podoplanin antibody
10R-P155a	Fitzgerald	100 ug	EUR 543
Description: Hamster monoclonal Podoplanin antibody

Podoplanin antibody
10R-7662	Fitzgerald	100 ug	EUR 629
Description: Mouse monoclonal Podoplanin antibody

Podoplanin antibody
10R-7663	Fitzgerald	100 ug	EUR 629
Description: Hamster monoclonal Podoplanin antibody

Podoplanin antibody
10R-7664	Fitzgerald	100 ug	EUR 629
Description: Mouse monoclonal Podoplanin antibody

Podoplanin Antibody
49474-100ul	SAB	100ul	EUR 333

Podoplanin Antibody
49474-50ul	SAB	50ul	EUR 239

Podoplanin Antibody
DF12456	Affbiotech	200ul	EUR 304
Description: Podoplanin antibody detects endogenous levels of Podoplanin.

Podoplanin antibody
70R-PR007	Fitzgerald	100 ug	EUR 422
Description: Affinity purified Rabbit polyclonal Podoplanin antibody

Podoplanin antibody
70R-50819	Fitzgerald	100 ul	EUR 244
Description: Purified Polyclonal Podoplanin antibody

Podoplanin antibody
70R-6816	Fitzgerald	50 ug	EUR 467
Description: Rabbit polyclonal Podoplanin antibody raised against the N terminal of PDPN

Podoplanin antibody
70R-6817	Fitzgerald	50 ug	EUR 467
Description: Rabbit polyclonal Podoplanin antibody raised against the middle region of PDPN

Podoplanin Antibody
P1051-01m	SAB	0.1m	EUR 209

Podoplanin Antibody
P1051-1ml	SAB	1ml	EUR 941

Polyclonal Goat anti-GST α-form
GST-ANTI-1	Detroit R&D	50 uL	EUR 280

Polyclonal Goat anti-GST μ-form
GST-ANTI-2	Detroit R&D	50 uL	EUR 280

Polyclonal Goat anti-GST p-form
GST-ANTI-3	Detroit R&D	50 uL	EUR 280

Mouse Podoplanin (PDPN) ELISA Kit
DLR-PDPN-Mu-48T	DL Develop	48T	EUR 527
Should the Mouse Podoplanin (PDPN) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Podoplanin (PDPN) in samples from tissue homogenates, cell lysates or other biological fluids.

Mouse Podoplanin (PDPN) ELISA Kit
DLR-PDPN-Mu-96T	DL Develop	96T	EUR 688
Should the Mouse Podoplanin (PDPN) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Podoplanin (PDPN) in samples from tissue homogenates, cell lysates or other biological fluids.

Recombinant Mouse Podoplanin (C-Fc)
CU73-10ug	Novoprotein	10ug	EUR 131
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Mouse Podoplanin (C-Fc)
CU73-1mg	Novoprotein	1mg	EUR 1674
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Mouse Podoplanin (C-Fc)
CU73-500ug	Novoprotein	500ug	EUR 1166
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Mouse Podoplanin (C-Fc)
CU73-50ug	Novoprotein	50ug	EUR 273
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Mouse Podoplanin (PDPN) ELISA Kit
20-abx154564	Abbexa	EUR 7378.00 EUR 3933.00 EUR 911.00	10 × 96 tests 5 × 96 tests 96 tests
Shipped within 5-7 working days.

Mouse Podoplanin, Pdpn ELISA KIT
ELI-06723m	Lifescience Market	96 Tests	EUR 865

Mouse Podoplanin (PDPN) ELISA Kit
abx571749-96tests	Abbexa	96 tests	EUR 786
Shipped within 5-12 working days.

Mouse Podoplanin (PDPN) CLIA Kit
20-abx493858	Abbexa	EUR 7973.00 EUR 4246.00 EUR 981.00	10 × 96 tests 5 × 96 tests 96 tests
Please enquire.

Podoplanin (PDPN) Polyclonal Antibody (Mouse)
4-PAC719Mu01	Cloud-Clone	EUR 251.00 EUR 2576.00 EUR 640.00 EUR 316.00 EUR 215.00	100ul 10ml 1ml 200ul 20ul
Sequence of the immunogen: PDPN (Gly23~Val138) Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Rabbit polyclonal antibody against Mouse Podoplanin (PDPN)

Mouse Podoplanin (PDPN) ELISA Kit
SEC719Mu-10x96wellstestplate	Cloud-Clone	10x96-wells test plate	EUR 4862.4
The Intra-assay Precision is determined when 3 samples with low, middle and high level of Mouse Podoplanin (PDPN) were tested on 3 different plates, 8 replicates in each plate CV(%) = SD/meanX100 Intra-Assay: CV<10% Inter-Assay: CV<12%
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Podoplanin (PDPN) in tissue homogenates, cell lysates and other biological fluids.

Mouse Podoplanin (PDPN) ELISA Kit
SEC719Mu-1x48wellstestplate	Cloud-Clone	1x48-wells test plate	EUR 488.08
The Intra-assay Precision is determined when 3 samples with low, middle and high level of Mouse Podoplanin (PDPN) were tested on 3 different plates, 8 replicates in each plate CV(%) = SD/meanX100 Intra-Assay: CV<10% Inter-Assay: CV<12%
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Podoplanin (PDPN) in tissue homogenates, cell lysates and other biological fluids.

Mouse Podoplanin (PDPN) ELISA Kit
SEC719Mu-1x96wellstestplate	Cloud-Clone	1x96-wells test plate	EUR 654.4
The Intra-assay Precision is determined when 3 samples with low, middle and high level of Mouse Podoplanin (PDPN) were tested on 3 different plates, 8 replicates in each plate CV(%) = SD/meanX100 Intra-Assay: CV<10% Inter-Assay: CV<12%
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Podoplanin (PDPN) in tissue homogenates, cell lysates and other biological fluids.

Mouse Podoplanin (PDPN) ELISA Kit
SEC719Mu-5x96wellstestplate	Cloud-Clone	5x96-wells test plate	EUR 2644.8
The Intra-assay Precision is determined when 3 samples with low, middle and high level of Mouse Podoplanin (PDPN) were tested on 3 different plates, 8 replicates in each plate CV(%) = SD/meanX100 Intra-Assay: CV<10% Inter-Assay: CV<12%
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Podoplanin (PDPN) in tissue homogenates, cell lysates and other biological fluids.

Mouse Podoplanin (PDPN) ELISA Kit
4-SEC719Mu	Cloud-Clone	EUR 4913.00 EUR 2595.00 EUR 655.00	10 plates of 96 wells 5 plates of 96 wells 1 plate of 96 wells
Known also as Podoplanin elisa. Alternative names of the recognized antigen: GP40 GP36 Gp38 HT1A-1 OTS8 PA2.26 T1A T1A-2 Aggrus Glycoprotein 36 PA2.26 antigen T1-alpha Lung Type I Cell Membrane Associated Glycoprotein
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Mouse Podoplanin (PDPN) in samples from tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species.

Mouse Podoplanin(PDPN)ELISA kit
QY-E21215	Qayee Biotechnology	96T	EUR 361

Mouse Podoplanin (PDPN) ELISA Kit
RDR-PDPN-Mu-48Tests	Reddot Biotech	48 Tests	EUR 557

Mouse Podoplanin (PDPN) ELISA Kit
RDR-PDPN-Mu-96Tests	Reddot Biotech	96 Tests	EUR 774

Mouse Podoplanin (PDPN) ELISA Kit
RD-PDPN-Mu-48Tests	Reddot Biotech	48 Tests	EUR 533

Mouse Podoplanin (PDPN) ELISA Kit
RD-PDPN-Mu-96Tests	Reddot Biotech	96 Tests	EUR 740

Recombinant Human Podoplanin
7-05839	CHI Scientific	5µg	Ask for price

Recombinant Human Podoplanin
7-05840	CHI Scientific	25µg	Ask for price

Recombinant Human Podoplanin
7-05841	CHI Scientific	1mg	Ask for price

Podoplanin Blocking Peptide
33R-2420	Fitzgerald	100 ug	EUR 180
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of PDPN antibody, catalog no. 70R-6816

Podoplanin Blocking Peptide
33R-9441	Fitzgerald	100 ug	EUR 180
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of PDPN antibody, catalog no. 70R-6817

Podoplanin Blocking Peptide
DF12456-BP	Affbiotech	1mg	EUR 195

Podoplanin (PDPN) Antibody
20-abx008317	Abbexa	EUR 300.00 EUR 439.00 EUR 189.00	100 ul 200 ul 30 ul
Shipped within 5-10 working days.

Podoplanin (PDPN) Antibody
20-abx005408	Abbexa	EUR 411.00 EUR 592.00 EUR 182.00 EUR 314.00	100 ul 200 ul 20 ul 50 ul
Shipped within 5-10 working days.

Podoplanin (PDPN) Antibody
20-abx178065	Abbexa	EUR 1233.00 EUR 592.00	1 mg 200 ug
Please enquire.

Podoplanin (PDPN) Antibody
20-abx178066	Abbexa	EUR 1302.00 EUR 620.00	1 mg 200 ug
Please enquire.

Podoplanin (PDPN) Antibody
20-abx178067	Abbexa	EUR 1414.00 EUR 662.00	1 mg 200 ug
Please enquire.

Podoplanin (PDPN) Antibody
20-abx211099	Abbexa	EUR 411.00 EUR 300.00	100 ul 50 ul
Shipped within 5-10 working days.

Podoplanin (PDPN) Antibody
20-abx114559	Abbexa	EUR 732.00 EUR 398.00	150 ul 50 ul
Shipped within 5-10 working days.

Podoplanin (PDPN) Antibody
20-abx123399	Abbexa	EUR 592.00 EUR 857.00 EUR 411.00	100 ul 200 ul 50 ul
Shipped within 5-10 working days.

Podoplanin (PDPN) Antibody
20-abx129101	Abbexa	EUR 425.00 EUR 133.00 EUR 1205.00 EUR 578.00 EUR 328.00	100 ug 10 ug 1 mg 200 ug 50 ug
Shipped within 5-7 working days.

Podoplanin (PDPN) Antibody
20-abx131102	Abbexa	EUR 439.00 EUR 133.00 EUR 1233.00 EUR 592.00 EUR 328.00	100 ug 10 ug 1 mg 200 ug 50 ug
Shipped within 5-7 working days.

Podoplanin (PDPN) Antibody
20-abx137407	Abbexa	EUR 704.00 EUR 328.00 EUR 230.00	100 ug 20 ug 5 ug
Shipped within 5-10 working days.

Podoplanin (PDPN) Antibody
20-abx174125	Abbexa	EUR 857.00 EUR 439.00	1 mg 200 ug
Please enquire.

Podoplanin (PDPN) Antibody
20-abx174126	Abbexa	EUR 913.00 EUR 467.00	1 mg 200 ug
Please enquire.

Podoplanin Blocking Peptide
20-abx063694	Abbexa	EUR 272.00 EUR 411.00	1 mg 5 mg
Shipped within 5-10 working days.

Podoplanin (PDPN) Protein
20-abx262003	Abbexa	EUR 4490.00 EUR 328.00 EUR 230.00	1 mg 25 ug 5 ug
Shipped within 5-10 working days.

Podoplanin Conjugated Antibody
C49474	SAB	100ul	EUR 397

Podoplanin (PDPN) Antibody
20-abx339428	Abbexa	EUR 411.00 EUR 300.00	100 ul 50 ul
Shipped within 5-10 working days.

Podoplanin (PDPN) Antibody
abx236598-100ug	Abbexa	100 ug	EUR 551
Shipped within 5-12 working days.

Podoplanin (PDPN) Antibody
abx236599-100ug	Abbexa	100 ug	EUR 551
Shipped within 5-12 working days.

Podoplanin (PDPN) Antibody
abx433110-200ul	Abbexa	200 ul	EUR 384
Shipped within 1-3 working days.

Recombinant Podoplanin (PDPN)
4-RPC719Hu01	Cloud-Clone	EUR 413.60 EUR 214.00 EUR 1276.00 EUR 492.00 EUR 884.00 EUR 340.00 EUR 3040.00	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Uniprot ID: Q86YL7 Buffer composition: PBS, pH 7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. Form: Freeze-dried powder Predicted Molecular Mass (KD): 18.8kDa Isoelectric Point: Inquire
Description: Recombinant Human Podoplanin expressed in: E.coli

Recombinant Podoplanin (PDPN)
4-RPC719Mu01	Cloud-Clone	EUR 458.40 EUR 226.00 EUR 1444.00 EUR 548.00 EUR 996.00 EUR 370.00 EUR 3460.00	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Uniprot ID: Q62011 Buffer composition: PBS, pH 7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. Form: Freeze-dried powder Predicted Molecular Mass (KD): 42.2kDa Isoelectric Point: Inquire
Description: Recombinant Mouse Podoplanin expressed in: E.coli

Syrian Hamster Anti-Mouse Podoplanin (gp38) Monoclonal antibody, clone 8.1.1
CABT-L4294-1mg	Creative Diagnostics	1 mg	EUR 897

Syrian Hamster Anti-Mouse Podoplanin (gp38) Monoclonal antibody, clone 8.1.1
CABT-L4294-5mg	Creative Diagnostics	5 mg	EUR 2405

ELISA kit for Mouse PDPN (Podoplanin)
E-EL-M2409	Elabscience Biotech	1 plate of 96 wells	EUR 534
Gentaur's PDPN ELISA kit utilizes the Sandwich-ELISA principle. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to Mouse PDPN. Standards or samples are added to the micro ELISA plate wells and combined with th Show more
Description: A sandwich ELISA kit for quantitative measurement of Mouse PDPN (Podoplanin) in samples from Serum, Plasma, Cell supernatant

ELISA kit for Mouse PDPN (Podoplanin)
ELK7080	ELK Biotech	1 plate of 96 wells	EUR 432
The microtiter plate provided in this kit has been pre-coated with an antibody specific to Podoplanin (PDPN). Standards or samples are then added to the appropriate microtiter plate wells with a biotin-conjugated antibody specific to Podoplanin (PDPN Show more
Description: A sandwich ELISA kit for detection of Podoplanin from Mouse in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

Podoplanin (PDPN) Polyclonal Antibody (Mouse), APC
4-PAC719Mu01-APC	Cloud-Clone	EUR 351.00 EUR 3365.00 EUR 935.00 EUR 449.00 EUR 222.00	100ul 10ml 1ml 200ul 20ul
Sequence of the immunogen: PDPN (Gly23~Val138) Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Rabbit polyclonal antibody against Mouse Podoplanin (PDPN). This antibody is labeled with APC.

Podoplanin (PDPN) Polyclonal Antibody (Mouse), Biotinylated
4-PAC719Mu01-Biotin	Cloud-Clone	EUR 316.00 EUR 2526.00 EUR 744.00 EUR 387.00 EUR 221.00	100ul 10ml 1ml 200ul 20ul
Sequence of the immunogen: PDPN (Gly23~Val138) Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Rabbit polyclonal antibody against Mouse Podoplanin (PDPN). This antibody is labeled with Biotin.

Podoplanin (PDPN) Polyclonal Antibody (Mouse), Cy3
4-PAC719Mu01-Cy3	Cloud-Clone	EUR 427.00 EUR 4445.00 EUR 1205.00 EUR 557.00 EUR 254.00	100ul 10ml 1ml 200ul 20ul
Sequence of the immunogen: PDPN (Gly23~Val138) Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Rabbit polyclonal antibody against Mouse Podoplanin (PDPN). This antibody is labeled with Cy3.

Podoplanin (PDPN) Polyclonal Antibody (Mouse), FITC
4-PAC719Mu01-FITC	Cloud-Clone	EUR 301.00 EUR 2712.00 EUR 768.00 EUR 379.00 EUR 197.00	100ul 10ml 1ml 200ul 20ul
Sequence of the immunogen: PDPN (Gly23~Val138) Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Rabbit polyclonal antibody against Mouse Podoplanin (PDPN). This antibody is labeled with FITC.

Podoplanin (PDPN) Polyclonal Antibody (Mouse), HRP
4-PAC719Mu01-HRP	Cloud-Clone	EUR 321.00 EUR 2933.00 EUR 827.00 EUR 405.00 EUR 209.00	100ul 10ml 1ml 200ul 20ul
Sequence of the immunogen: PDPN (Gly23~Val138) Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Rabbit polyclonal antibody against Mouse Podoplanin (PDPN). This antibody is labeled with HRP.

Podoplanin (PDPN) Polyclonal Antibody (Mouse), PE
4-PAC719Mu01-PE	Cloud-Clone	EUR 301.00 EUR 2712.00 EUR 768.00 EUR 379.00 EUR 197.00	100ul 10ml 1ml 200ul 20ul
Sequence of the immunogen: PDPN (Gly23~Val138) Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Rabbit polyclonal antibody against Mouse Podoplanin (PDPN). This antibody is labeled with PE.