An efficient virus-induced gene silencing
Clem
June 13, 2021
Gene-Modifying Applied sciences Paired With Viral Vectors for Translational Analysis Into Neurodegenerative Ailments
Ailments of the central nervous system (CNS) have traditionally been among the many most troublesome to deal with utilizing typical pharmacological approaches. This is because of a confluence of things, together with the restricted regenerative capability and general complexity of the mind, issues related to repeated drug administration, and difficulties delivering medication throughout the blood-brain barrier (BBB). Viral-mediated gene switch represents a pretty various for the supply of therapeutic cargo to the nervous system. Crucially, it often requires solely a single injection, whether or not that be a gene substitute technique for an inherited dysfunction or the supply of a genome- or epigenome-modifying assemble for remedy of CNS illnesses and issues.
It’s thus comprehensible that appreciable effort has been put in direction of the event of improved vector techniques for gene switch into the CNS. Totally different viral vectors are in fact tailor-made to their particular purposes, however they typically ought to share a number of key properties. The best viral vector incorporates a high-packaging capability, environment friendly gene switch paired with sturdy and sustained expression, lack of oncogenicity, toxicity and pathogenicity, and scalable manufacturing for medical purposes. On this evaluation, we’ll dedicate consideration to viral vectors derived from human immunodeficiency virus sort 1 (lentiviral vectors; LVs) and adeno-associated virus (AAVs).
The excessive curiosity in these viral supply techniques vectors is because of: (i) sturdy supply and long-lasting expression; (ii) environment friendly transduction into postmitotic cells, together with the mind; (iii) low immunogenicity and toxicity; and (iv) compatibility with superior manufacturing strategies. Right here, we’ll define primary points of LV and AAV biology, notably specializing in approaches and strategies aiming to reinforce viral security.
We may also allocate a good portion of this evaluation to the event and use of LVs and AAVs for supply into the CNS, with a concentrate on the genome and epigenome-editing instruments primarily based on clustered repeatedly interspaced quick palindromic repeats/CRISPR-associated protein 9 (CRISPR/Cas 9) and the event of novel methods for the remedy of neurodegenerative illnesses (NDDs).

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anti-Galectin 1 |
YF-PA12945 |
Abfrontier |
100 ug |
EUR 403 |
Description: Rabbit polyclonal to Galectin 1 |
Rabbit Polyclonal antibody Anti-CRBN |
Anti-CRBN |
ImmunoStep |
50 µg |
EUR 349 |
Anti-Galectin 1 Antibody |
A00470-2 |
BosterBio |
100ug/vial |
EUR 294 |
Anti-Galectin-1 antibody |
STJ98716 |
St John's Laboratory |
200 µl |
EUR 197 |
Description: Rabbit polyclonal to Galectin-1. |
Anti-Galectin-1 antibody |
STJ93201 |
St John's Laboratory |
200 µl |
EUR 197 |
Description: Rabbit polyclonal to Galectin-1. |
anti- Galectin-1 antibody |
FNab03314 |
FN Test |
100µg |
EUR 505.25 |
|
Description: Antibody raised against Galectin-1 |
anti- Galectin-1 antibody |
FNab03315 |
FN Test |
100µg |
EUR 548.75 |
|
Description: Antibody raised against Galectin-1 |
Anti-Galectin 1 (1A8) |
YF-MA13984 |
Abfrontier |
100 ug |
EUR 363 |
Description: Mouse monoclonal to Galectin 1 |
Anti-Galectin 1/LGALS1 Antibody |
PA1422 |
BosterBio |
100ug/vial |
EUR 334 |
Anti-Galectin 1/LGALS1 Antibody |
PB9240 |
BosterBio |
100ug/vial |
EUR 334 |
Anti-Galectin 1/Lgals1 Antibody |
A00470 |
BosterBio |
100ug/vial |
EUR 334 |
Anti-Galectin 1 Biotinylated Antibody |
A00470-Biotin |
BosterBio |
50ug/vial |
EUR 294 |
anti-Galectin 1 (1E8-1B2) |
LF-MA10174 |
Abfrontier |
100 ug |
EUR 363 |
Description: Mouse monoclonal to Galectin 1 |
Anti-Galectin-13 (GAL13) / Placental Protein 13 (PP13) Monoclonal Antibody |
M08143-1 |
BosterBio |
100ug/vial |
EUR 397 |
Description: Mouse Monoclonal Galectin-13 (GAL13) / Placental Protein 13 (PP13) Antibody. Validated in IHC and tested in Human. |
anti-Galectin 3 |
YF-PA12946 |
Abfrontier |
50 ug |
EUR 363 |
Description: Mouse polyclonal to Galectin 3 |
anti-Galectin 3 |
YF-PA12947 |
Abfrontier |
100 ul |
EUR 403 |
Description: Rabbit polyclonal to Galectin 3 |
anti-Galectin 3 |
YF-PA12948 |
Abfrontier |
100 ug |
EUR 403 |
Description: Rabbit polyclonal to Galectin 3 |
anti-Galectin 8 |
YF-PA12951 |
Abfrontier |
50 ul |
EUR 363 |
Description: Mouse polyclonal to Galectin 8 |
anti-Galectin 3 |
YF-PA24079 |
Abfrontier |
50 ul |
EUR 334 |
Description: Mouse polyclonal to Galectin 3 |
anti-galectin 9 |
YF-PA24081 |
Abfrontier |
50 ul |
EUR 334 |
Description: Mouse polyclonal to galectin 9 |
anti-Galectin 13 |
YF-PA18585 |
Abfrontier |
50 ug |
EUR 363 |
Description: Mouse polyclonal to Galectin 13 |
Polyclonal Goat anti-GST μ-form |
GST-ANTI-2 |
Detroit R&D |
50 uL |
EUR 280 |
Polyclonal Goat anti-GST p-form |
GST-ANTI-3 |
Detroit R&D |
50 uL |
EUR 280 |
Anti-human Galectin-3 antibody |
STJ15100163 |
St John's Laboratory |
250 µg |
EUR 336 |
Description: This monoclonal antibody is for studies of antigen expression in cells and tissue sections using immunocytochemistry and immunoprecipitation |
LGALS7 Human, Galectin-7 Human Recombinant Protein, His Tag |
PROTP47929-1 |
BosterBio |
Regular: 20ug |
EUR 317 |
Description: Galectin-7 Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 156 amino acids (1-136 a.a.) and having a molecular mass of 17.2kDa. ;The Galectin-7 is purified by proprietary chromatographic techniques. |
LGALS3 Human, Galectin-3 Human Recombinant Protein, His Tag |
PROTP17931-1 |
BosterBio |
Regular: 25ug |
EUR 317 |
Description: LGALS3 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 270 amino acids (1-250 a.a.) and having a molecular mass of 28.3 kDa._x000D_ The LGALS3 is fused to a 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques. _x000D_ |
LGALS8 Human, Galectin-8 Human Recombinant Protein, His Tag |
PROTO00214-1 |
BosterBio |
Regular: 10ug |
EUR 317 |
Description: LGALS8 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 337 amino acids (1-317 a.a.) and having a molecular mass of 37.9 kDa. The LGALS8 is fused to a 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques. |
Human Galectin-3 (Gal-3) AssayMax ELISA Kit |
EG3311-1 |
AssayPro |
96 Well Plate |
EUR 477 |
Human Galectin-4 (Gal-4) AssayMax ELISA Kit |
EG3312-1 |
AssayPro |
96 Well Plate |
EUR 477 |
Human Galectin-1 (LGALS1) |
1-CSB-EP012882HU |
Cusabio |
-
EUR 380.00
-
EUR 214.00
-
EUR 1309.00
-
EUR 560.00
-
EUR 873.00
-
EUR 262.00
|
- 100ug
- 10ug
- 1MG
- 200ug
- 500ug
- 50ug
|
|
Description: Recombinant Human Galectin-1(LGALS1) expressed in E.coli |
Human Galectin-1 (LGALS1) |
1-CSB-EP012882HUb1 |
Cusabio |
-
EUR 380.00
-
EUR 214.00
-
EUR 1309.00
-
EUR 560.00
-
EUR 873.00
-
EUR 262.00
|
- 100ug
- 10ug
- 1MG
- 200ug
- 500ug
- 50ug
|
|
Description: Recombinant Human Galectin-1(LGALS1) expressed in E.coli |
Human Galectin 1 Protein |
20-abx066725 |
Abbexa |
-
EUR 620.00
-
EUR 272.00
-
EUR 1859.00
-
EUR 732.00
-
EUR 453.00
|
- 100 ug
- 10 ug
- 1 mg
- 200 ug
- 50 ug
|
|
Recombinant Human Galectin-1 |
7-00427 |
CHI Scientific |
10µg |
Ask for price |
Recombinant Human Galectin-1 |
7-00428 |
CHI Scientific |
50µg |
Ask for price |
Galectin-1, human recombinant |
4648-10 |
Biovision |
|
EUR 142 |
Galectin-1, human recombinant |
4648-1000 |
Biovision |
|
EUR 1648 |
Galectin-1, human recombinant |
4648-50 |
Biovision |
|
EUR 262 |
Anti-Galectin 3 antibody |
STJ190057 |
St John's Laboratory |
200 µl |
EUR 197 |
Description: Unconjugated Mouse monoclonal to Galectin 3 (AS1A24) |
Anti-Galectin-9 Antibody |
A03415 |
BosterBio |
100ul |
EUR 397 |
Description: Rabbit Polyclonal Antibody for Galectin-9 Antibody (LGALS9) detection.tested for WB in Human, Mouse, Rat. |
Anti-Galectin-3 antibody |
STJ96945 |
St John's Laboratory |
200 µl |
EUR 197 |
Description: Galectin-3 is a protein encoded by the LGALS3 gene which is approximately 26,1 kDa. Galectin-3 is localised to the cytoplasm and nucleus. It is involved in NF-kappaB signalling, advanced glycosylation end product receptor signalling and cell adhesion. It is a galactose-specific lectin which binds IgE and may mediate the stimulation by CSPG4 of endothelial cells migration along with the alpha-3, beta-1 integrin. It is characterized by an N-terminal proline-rich tandem repeat domain and a single C-terminal carbohydrate recognition domain. Galectin-3 is expressed mainly in the colonic epithelium and is also abundantly expressed in activated macrophages. Mutations in the LGALS3 gene may result in follicular adenoma and thyroid cancer. STJ96945 was developed from clone 6G2 and was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. This antibody detects endogenous galectin-3 proteins. |
Anti-Galectin-3 antibody |
STJ97549 |
St John's Laboratory |
200 µl |
EUR 197 |
Description: Mouse monoclonal to Galectin-3 (6B8). |
Anti-Galectin-3 antibody |
STJ97550 |
St John's Laboratory |
200 µl |
EUR 197 |
Description: Mouse monoclonal to Galectin-3 (8D7). |
Anti-Galectin-3 antibody |
STJ97551 |
St John's Laboratory |
200 µl |
EUR 197 |
Description: Mouse monoclonal to Galectin-3 (5D9). |
Anti-Galectin-3 antibody |
STJ97601 |
St John's Laboratory |
200 µl |
EUR 197 |
Description: Mouse monoclonal to Galectin-3 (2F9). |
Anti-Galectin-3 antibody |
STJ97604 |
St John's Laboratory |
200 µl |
EUR 197 |
Description: Mouse monoclonal to Galectin-3 (16E6). |
Anti-Galectin-3 antibody |
STJ97605 |
St John's Laboratory |
200 µl |
EUR 197 |
Description: Mouse monoclonal to Galectin-3 (1H4). |
Anti-Galectin-3 antibody |
STJ97715 |
St John's Laboratory |
200 µl |
EUR 197 |
Description: Mouse monoclonal to Galectin-3. |
Anti-Galectin-2 antibody |
STJ93202 |
St John's Laboratory |
200 µl |
EUR 197 |
Description: Rabbit polyclonal to Galectin-2. |
Anti-Galectin-4 antibody |
STJ93203 |
St John's Laboratory |
200 µl |
EUR 197 |
Description: Rabbit polyclonal to Galectin-4. |
Anti-Galectin-7 antibody |
STJ93204 |
St John's Laboratory |
200 µl |
EUR 197 |
Description: Rabbit polyclonal to Galectin-7. |
Anti-Galectin-8 antibody |
STJ93205 |
St John's Laboratory |
200 µl |
EUR 197 |
Description: Rabbit polyclonal to Galectin-8. |
Anti-Galectin-9 antibody |
STJ93206 |
St John's Laboratory |
200 µl |
EUR 197 |
Description: Rabbit polyclonal to Galectin-9. |
anti- Galectin 2 antibody |
FNab03310 |
FN Test |
100µg |
EUR 585 |
|
Description: Antibody raised against Galectin 2 |
anti- Galectin 4 antibody |
FNab03311 |
FN Test |
100µg |
EUR 505.25 |
|
Description: Antibody raised against Galectin 4 |
anti- Galectin 8 antibody |
FNab03312 |
FN Test |
100µg |
EUR 505.25 |
|
Description: Antibody raised against Galectin 8 |
anti- Galectin 9 antibody |
FNab03313 |
FN Test |
100µg |
EUR 505.25 |
|
Description: Antibody raised against Galectin 9 |
anti- Galectin-3 antibody |
FNab03316 |
FN Test |
100µg |
EUR 505.25 |
|
Description: Antibody raised against Galectin-3 |
anti- Galectin-3 antibody |
FNab03317 |
FN Test |
100µg |
EUR 548.75 |
|
Description: Antibody raised against Galectin-3 |
anti- Galectin-7 antibody |
FNab03318 |
FN Test |
100µg |
EUR 505.25 |
|
Description: Antibody raised against Galectin-7 |
anti-Galectin-3 (6G2) |
LF-MA20336 |
Abfrontier |
100 ug |
EUR 354 |
Description: Mouse monoclonal to Galectin-3 |
Anti-Galectin 8 (3E5) |
YF-MA13986 |
Abfrontier |
100 ug |
EUR 363 |
Description: Mouse monoclonal to Galectin 8 |
Anti Human Galectin-3 Polyclonal Antibody |
KH040 |
Sceti |
|
EUR 649 |
Description: The Anti Human Galectin-3 Polyclonal Antibody is available in Europe and for worldwide shipping via Gentaur. |
Anti-Galectin-1 / Human Placental Lactogen (hPL) Monoclonal Antibody |
M00470 |
BosterBio |
100ug/vial |
EUR 397 |
Description: Mouse Monoclonal Galectin-1 / Human Placental Lactogen (hPL) Antibody. Validated in IHC and tested in Human. |
Galectin-1 (LGAS1) |
PR27143 |
Neuromics |
50 ug |
EUR 318 |
Galectin 1 Antibody |
49673-100ul |
SAB |
100ul |
EUR 333 |
Galectin 1 Antibody |
49673-50ul |
SAB |
50ul |
EUR 239 |
Galectin-1 Protein |
20-abx261634 |
Abbexa |
-
EUR 3418.00
-
EUR 328.00
-
EUR 230.00
|
|
|
Galectin-1 Protein |
20-abx263505 |
Abbexa |
-
EUR 230.00
-
EUR 1790.00
-
EUR 328.00
|
|
|
Galectin-1 Antibody |
3596-100 |
Biovision |
|
EUR 316 |
Galectin-1 Antibody |
3596-30T |
Biovision |
|
EUR 146 |
Galectin 1 protein |
30R-1385 |
Fitzgerald |
100 ug |
EUR 224 |
Description: Purified recombinant Human Galectin 1 protein |
Galectin 1 protein |
30R-2371 |
Fitzgerald |
50 ug |
EUR 353 |
Description: Purified recombinant Human Galectin 1 protein |
Galectin 1 protein |
30R-AG003 |
Fitzgerald |
10 ug |
EUR 133 |
Description: Purified recombinant Human Galectin 1 protein |
Galectin 1 antibody |
70R-11939 |
Fitzgerald |
100 ug |
EUR 403 |
Description: Rabbit polyclonal Galectin 1 antibody |
Galectin 1 antibody |
70R-13963 |
Fitzgerald |
100 ug |
EUR 322 |
Description: Affinity purified Rabbit polyclonal Galectin 1 antibody |
Galectin 1 antibody |
70R-49997 |
Fitzgerald |
100 ul |
EUR 244 |
Description: Purified Polyclonal Galectin 1 antibody |
An environment friendly virus-induced gene silencing (VIGS) system for purposeful genomics in Brassicas utilizing a cabbage leaf curl virus (CaLCuV)-based vector
CaLCuV-based VIGS successfully works in cabbage and contributes to environment friendly purposeful genomics analysis in Brassica crop species. Virus-induced gene silencing (VIGS), a posttranscriptional gene silencing methodology, is an efficient approach for analysing the capabilities of genes in vegetation. Nevertheless, no VIGS vectors have been obtainable for Brassica oleracea till now. Right here, tobacco rattle virus (TRV), pTYs and cabbage leaf curl virus (CaLCuV) gene-silencing vectors (PCVA/PCVB) had been chosen to enhance the VIGS system in cabbage utilizing the phytoene desaturase (PDS) gene as an environment friendly visible indicator of VIGS. We efficiently silenced the expression of PDS and noticed photobleaching phenomena in cabbage in response to pTYs and CaLCuV, with the latter being simpler to function and cheaper.
The parameters doubtlessly affecting the silencing effectivity of VIGS by CaLCuV in cabbage, together with the focusing on fragment technique, inoculation methodology and incubation temperature, had been then in contrast. The optimized CaLCuV-based VIGS system includes the next: an roughly 500 bp insert sequence, an Agrobacterium OD600 of 1.0, use of the vacuum osmosis methodology utilized on the bud stage, and an incubation temperature of 22 °C.
Utilizing these parameters, we achieved a steady silencing effectivity of 65%. To additional take a look at the effectiveness of the system, we chosen the Mg-chelatase H subunit (ChlH) gene in cabbage and knocked down its expression, and we noticed yellow leaves, as anticipated. We efficiently utilized the CaLCuV-based VIGS system to 2 different consultant Brassica crop species, B. rapa and B. nigra, and thus expanded the appliance scope of this method. Our VIGS system described right here will contribute to environment friendly purposeful genomics analysis in Brassica crop species.
Ocular Gene Remedy with Adeno-associated Virus Vectors: Present Outlook for Sufferers and Researchers
On this “Perspective”, we talk about ocular gene remedy – the affected person’s perspective, the assorted methods of gene substitute and gene modifying, the place of adeno-associated virus vectors, routes of supply to the attention and the remaining query – “why does immunity proceed to restrict efficacy?” Via the coordinated efforts of sufferers, researchers, granting companies and business, and after a few years of pre-clinical research, biochemical, mobile, and animal fashions, we’re seeing medical trials emerge for a lot of beforehand untreatable heritable ocular issues.
The pathway to therapies has been led by the profitable remedy of the RPE65 type of Leber congenital amaurosis with LUXTURNA TM . In some instances, immune reactions to the vectors proceed to happen, limiting efficacy.
The underlying mechanisms of irritation require additional research, and new vectors have to be designed that restrict the triggers of immunity. Researchers finding out ocular gene therapies and clinicians enrolling sufferers in medical trials should acknowledge the present limitations of those therapies to correctly handle expectations and keep away from disappointment, however we imagine that gene therapies are effectively on their solution to profitable, widespread utilization to deal with heritable ocular issues.
EBV-miR-BART12 accelerates migration and invasion in EBV-associated most cancers cells by focusing on tubulin polymerization-promoting protein 1
Epstein-Barr virus (EBV) an infection results in cancers with an epithelial origin, akin to nasopharyngeal most cancers and gastric most cancers, in addition to a number of blood cell-based malignant tumors, akin to lymphoma. Apparently, EBV can also be the primary virus discovered to hold genes encoding miRNAs. EBV encodes 25 kinds of pre-miRNAs that are lastly processed into 44 mature miRNAs. Most EBV-encoded miRNAs had been discovered to be concerned within the prevalence and improvement of EBV-related tumors.
Nevertheless, the perform of EBV-miR-BART12 stays unclear. The findings of the present research revealed that EBV-miR-BART12 binds to the three’UTR area of Tubulin Polymerization-Selling Protein 1 (TPPP1) mRNA and downregulates TPPP1, thereby selling the invasion and migration of EBV-related cancers, akin to nasopharyngeal most cancers and gastric most cancers.
The mechanism underlying this course of was discovered to be the inhibition of TPPP1 by EBV-miRNA-BART12, which, in flip, inhibits the acetylation of α-tubulin, and promotes the dynamic meeting of microtubules, remodels the cytoskeleton, and enhances the acetylation of β-catenin. β-catenin prompts epithelial to mesenchymal transition (EMT).
These two processes synergistically promote the invasion and metastasis of tumor cells. To one of the best of our information, that is the primary research to disclose the function of EBV-miRNA-BART12 within the improvement of EBV-related tumors in addition to the mechanism underlying this course of, and suggests potential targets and methods for the remedy of EBV-related tumors.
Anti-Podoplanin Rabbit Monoclonal Antibody |
M01124-1 |
BosterBio |
100ug/vial |
EUR 397 |
Description: Rabbit Monoclonal Podoplanin Antibody. Validated in WB and tested in Human, Mouse, Rat. |
Anti-Podoplanin Rabbit Monoclonal Antibody |
M01124-2 |
BosterBio |
100ug/vial |
EUR 397 |
Description: Rabbit Monoclonal Podoplanin Antibody. Validated in WB and tested in Human. |
Anti-Podoplanin/gp36/PDPN Antibody |
PA1411 |
BosterBio |
100ug/vial |
EUR 294 |
Anti-Podoplanin/gp36/PDPN Antibody |
PA1674 |
BosterBio |
100ug/vial |
EUR 294 |
Anti-Podoplanin/gp36/PDPN Antibody |
PA1675 |
BosterBio |
100ug/vial |
EUR 294 |
Anti-Podoplanin/gp36/PDPN Antibody |
A01124 |
BosterBio |
100ug/vial |
EUR 294 |
Anti-D2-40/Podoplanin antibody |
STJ190048 |
St John's Laboratory |
200 µl |
EUR 197 |
Description: Unconjugated Mouse monoclonal to D2-40/Podoplanin (7D1) |
Mouse Podoplanin (PDPN) Protein |
20-abx650139 |
Abbexa |
-
EUR 648.00
-
EUR 272.00
-
EUR 1943.00
-
EUR 759.00
-
EUR 467.00
|
- 100 ug
- 10 ug
- 1 mg
- 200 ug
- 50 ug
|
|
Mouse Podoplanin ELISA kit |
E03P0082-192T |
BlueGene |
192 tests |
EUR 1270 |
|
Description: A sandwich ELISA for quantitative measurement of Mouse Podoplanin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Mouse Podoplanin ELISA kit |
E03P0082-48 |
BlueGene |
1 plate of 48 wells |
EUR 520 |
|
Description: A sandwich ELISA for quantitative measurement of Mouse Podoplanin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Mouse Podoplanin ELISA kit |
E03P0082-96 |
BlueGene |
1 plate of 96 wells |
EUR 685 |
|
Description: A sandwich ELISA for quantitative measurement of Mouse Podoplanin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Mouse Anti-Human Podoplanin monoclonal antibody, clone JID761 |
CABT-L2919-100uL500uL |
Creative Diagnostics |
100 uL, 500 uL |
EUR 502 |
Podoplanin Antibody |
P1051-01m |
SAB |
0.1m |
EUR 209 |
Podoplanin Antibody |
P1051-1ml |
SAB |
1ml |
EUR 941 |
Podoplanin Antibody |
49474-100ul |
SAB |
100ul |
EUR 333 |
Podoplanin Antibody |
49474-50ul |
SAB |
50ul |
EUR 239 |
Podoplanin Antibody |
DF12456 |
Affbiotech |
200ul |
EUR 304 |
Description: Podoplanin antibody detects endogenous levels of Podoplanin. |
Podoplanin antibody |
10R-7662 |
Fitzgerald |
100 ug |
EUR 629 |
Description: Mouse monoclonal Podoplanin antibody |
Podoplanin antibody |
10R-7663 |
Fitzgerald |
100 ug |
EUR 629 |
Description: Hamster monoclonal Podoplanin antibody |
Podoplanin antibody |
10R-7664 |
Fitzgerald |
100 ug |
EUR 629 |
Description: Mouse monoclonal Podoplanin antibody |
Podoplanin antibody |
10R-P133a |
Fitzgerald |
100 ug |
EUR 507 |
Description: Mouse monoclonal Podoplanin antibody |
Podoplanin antibody |
10R-P155a |
Fitzgerald |
100 ug |
EUR 543 |
Description: Hamster monoclonal Podoplanin antibody |
Podoplanin antibody |
70R-6816 |
Fitzgerald |
50 ug |
EUR 467 |
Description: Rabbit polyclonal Podoplanin antibody raised against the N terminal of PDPN |
Podoplanin antibody |
70R-6817 |
Fitzgerald |
50 ug |
EUR 467 |
Description: Rabbit polyclonal Podoplanin antibody raised against the middle region of PDPN |
Podoplanin antibody |
70R-PR007 |
Fitzgerald |
100 ug |
EUR 422 |
Description: Affinity purified Rabbit polyclonal Podoplanin antibody |
Podoplanin antibody |
70R-11540 |
Fitzgerald |
100 ug |
EUR 527 |
Description: Rabbit polyclonal Podoplanin antibody |
Podoplanin antibody |
70R-13952 |
Fitzgerald |
100 ug |
EUR 305 |
Description: Affinity purified Rabbit polyclonal Podoplanin antibody |
Podoplanin antibody |
70R-50819 |
Fitzgerald |
100 ul |
EUR 244 |
Description: Purified Polyclonal Podoplanin antibody |
Polyclonal Goat anti-GST α-form |
GST-ANTI-1 |
Detroit R&D |
50 uL |
EUR 280 |
Polyclonal Goat anti-GST μ-form |
GST-ANTI-2 |
Detroit R&D |
50 uL |
EUR 280 |
Polyclonal Goat anti-GST p-form |
GST-ANTI-3 |
Detroit R&D |
50 uL |
EUR 280 |
Mouse Podoplanin (PDPN) ELISA Kit |
20-abx154564 |
Abbexa |
-
EUR 7378.00
-
EUR 3933.00
-
EUR 911.00
|
- 10 × 96 tests
- 5 × 96 tests
- 96 tests
|
|
Mouse Podoplanin (PDPN) ELISA Kit |
abx571749-96tests |
Abbexa |
96 tests |
EUR 786 |
|
Mouse Podoplanin (PDPN) CLIA Kit |
20-abx493858 |
Abbexa |
-
EUR 7973.00
-
EUR 4246.00
-
EUR 981.00
|
- 10 × 96 tests
- 5 × 96 tests
- 96 tests
|
|
Mouse Podoplanin (PDPN) ELISA Kit |
RDR-PDPN-Mu-48Tests |
Reddot Biotech |
48 Tests |
EUR 557 |
Mouse Podoplanin (PDPN) ELISA Kit |
RDR-PDPN-Mu-96Tests |
Reddot Biotech |
96 Tests |
EUR 774 |
Mouse Podoplanin (PDPN) ELISA Kit |
RD-PDPN-Mu-48Tests |
Reddot Biotech |
48 Tests |
EUR 533 |
Mouse Podoplanin (PDPN) ELISA Kit |
RD-PDPN-Mu-96Tests |
Reddot Biotech |
96 Tests |
EUR 740 |
Mouse Podoplanin (PDPN) ELISA Kit |
DLR-PDPN-Mu-48T |
DL Develop |
48T |
EUR 527 |
|
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Podoplanin (PDPN) in samples from tissue homogenates, cell lysates or other biological fluids. |
Mouse Podoplanin (PDPN) ELISA Kit |
DLR-PDPN-Mu-96T |
DL Develop |
96T |
EUR 688 |
|
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Podoplanin (PDPN) in samples from tissue homogenates, cell lysates or other biological fluids. |
Podoplanin (PDPN) Polyclonal Antibody (Mouse) |
4-PAC719Mu01 |
Cloud-Clone |
-
EUR 251.00
-
EUR 2576.00
-
EUR 640.00
-
EUR 316.00
-
EUR 215.00
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
Description: A Rabbit polyclonal antibody against Mouse Podoplanin (PDPN) |
Mouse Podoplanin (PDPN) ELISA Kit |
SEC719Mu-10x96wellstestplate |
Cloud-Clone |
10x96-wells test plate |
EUR 4862.4 |
|
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Podoplanin (PDPN) in tissue homogenates, cell lysates and other biological fluids. |
Mouse Podoplanin (PDPN) ELISA Kit |
SEC719Mu-1x48wellstestplate |
Cloud-Clone |
1x48-wells test plate |
EUR 488.08 |
|
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Podoplanin (PDPN) in tissue homogenates, cell lysates and other biological fluids. |
Mouse Podoplanin (PDPN) ELISA Kit |
SEC719Mu-1x96wellstestplate |
Cloud-Clone |
1x96-wells test plate |
EUR 654.4 |
|
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Podoplanin (PDPN) in tissue homogenates, cell lysates and other biological fluids. |
Mouse Podoplanin (PDPN) ELISA Kit |
SEC719Mu-5x96wellstestplate |
Cloud-Clone |
5x96-wells test plate |
EUR 2644.8 |
|
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Podoplanin (PDPN) in tissue homogenates, cell lysates and other biological fluids. |
Mouse Podoplanin (PDPN) ELISA Kit |
4-SEC719Mu |
Cloud-Clone |
-
EUR 4913.00
-
EUR 2595.00
-
EUR 655.00
|
- 10 plates of 96 wells
- 5 plates of 96 wells
- 1 plate of 96 wells
|
|
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Mouse Podoplanin (PDPN) in samples from tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. |
Recombinant Mouse Podoplanin (C-Fc) |
CU73-10ug |
Novoprotein |
10ug |
EUR 131 |
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
Recombinant Mouse Podoplanin (C-Fc) |
CU73-1mg |
Novoprotein |
1mg |
EUR 1674 |
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
Recombinant Mouse Podoplanin (C-Fc) |
CU73-500ug |
Novoprotein |
500ug |
EUR 1166 |
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
Recombinant Mouse Podoplanin (C-Fc) |
CU73-50ug |
Novoprotein |
50ug |
EUR 273 |
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
Podoplanin (PDPN) Antibody |
20-abx131102 |
Abbexa |
-
EUR 439.00
-
EUR 133.00
-
EUR 1233.00
-
EUR 592.00
-
EUR 328.00
|
- 100 ug
- 10 ug
- 1 mg
- 200 ug
- 50 ug
|
|
Podoplanin (PDPN) Antibody |
20-abx129101 |
Abbexa |
-
EUR 425.00
-
EUR 133.00
-
EUR 1205.00
-
EUR 578.00
-
EUR 328.00
|
- 100 ug
- 10 ug
- 1 mg
- 200 ug
- 50 ug
|
|
Podoplanin (PDPN) Antibody |
20-abx137407 |
Abbexa |
-
EUR 704.00
-
EUR 328.00
-
EUR 230.00
|
|
|
Podoplanin (PDPN) Antibody |
20-abx114559 |
Abbexa |
|
|
|
Podoplanin (PDPN) Antibody |
20-abx123399 |
Abbexa |
-
EUR 592.00
-
EUR 857.00
-
EUR 411.00
|
|
|
Podoplanin Blocking Peptide |
20-abx063694 |
Abbexa |
|
|
|
Podoplanin (PDPN) Antibody |
20-abx008317 |
Abbexa |
-
EUR 300.00
-
EUR 439.00
-
EUR 189.00
|
|
|
Podoplanin (PDPN) Antibody |
20-abx005408 |
Abbexa |
-
EUR 411.00
-
EUR 592.00
-
EUR 182.00
-
EUR 314.00
|
- 100 ul
- 200 ul
- 20 ul
- 50 ul
|
|
Recombinant Human Podoplanin |
7-05840 |
CHI Scientific |
25µg |
Ask for price |
Podoplanin (PDPN) Antibody |
abx433110-200ul |
Abbexa |
200 ul |
EUR 384 |
|
Podoplanin (PDPN) Protein |
20-abx262003 |
Abbexa |
-
EUR 4490.00
-
EUR 328.00
-
EUR 230.00
|
|
|
Podoplanin (PDPN) Antibody |
20-abx339428 |
Abbexa |
|
|
|
Podoplanin (PDPN) Antibody |
abx236598-100ug |
Abbexa |
100 ug |
EUR 551 |
|
Podoplanin (PDPN) Antibody |
abx236599-100ug |
Abbexa |
100 ug |
EUR 551 |
|
Podoplanin (PDPN) Antibody |
20-abx178065 |
Abbexa |
|
|
|
Podoplanin (PDPN) Antibody |
20-abx178066 |
Abbexa |
|
|
|
Podoplanin (PDPN) Antibody |
20-abx178067 |
Abbexa |
|
|
|
Podoplanin (PDPN) Antibody |
20-abx174125 |
Abbexa |
|
|
|
Podoplanin (PDPN) Antibody |
20-abx174126 |
Abbexa |
|
|
|
Podoplanin (PDPN) Antibody |
20-abx211099 |
Abbexa |
|
|
|
Podoplanin Conjugated Antibody |
C49474 |
SAB |
100ul |
EUR 397 |
Recombinant Podoplanin (PDPN) |
4-RPC719Hu01 |
Cloud-Clone |
-
EUR 413.60
-
EUR 214.00
-
EUR 1276.00
-
EUR 492.00
-
EUR 884.00
-
EUR 340.00
-
EUR 3040.00
|
- 100 ug
- 10ug
- 1 mg
- 200 ug
- 500 ug
- 50ug
- 5 mg
|
|
Description: Recombinant Human Podoplanin expressed in: E.coli |
Recombinant Podoplanin (PDPN) |
4-RPC719Mu01 |
Cloud-Clone |
-
EUR 458.40
-
EUR 226.00
-
EUR 1444.00
-
EUR 548.00
-
EUR 996.00
-
EUR 370.00
-
EUR 3460.00
|
- 100 ug
- 10ug
- 1 mg
- 200 ug
- 500 ug
- 50ug
- 5 mg
|
|
Description: Recombinant Mouse Podoplanin expressed in: E.coli |
Podoplanin Blocking Peptide |
DF12456-BP |
Affbiotech |
1mg |
EUR 195 |
Podoplanin Blocking Peptide |
33R-9441 |
Fitzgerald |
100 ug |
EUR 180 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of PDPN antibody, catalog no. 70R-6817 |
Podoplanin Blocking Peptide |
33R-2420 |
Fitzgerald |
100 ug |
EUR 180 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of PDPN antibody, catalog no. 70R-6816 |
Podoplanin Recombinant Protein |
91-478 |
ProSci |
0.05 mg |
EUR 448.25 |
Description: Podoplanin is a type-1 transmembrane protein that belongs to Podoplanin family. PDPN expressed in various specialized cell types throughout the body. It highly expressed in placenta, lung, skeletal muscle and brain, weakly expressed in brain, kidney and liver. In placenta, PDPN expressed on the apical plasma membrane of endothelium, in lung, expressed in alveolar epithelium. PDPN physiological function is related to its mucin-type character. PDPN may be involved in cell migration and/or actin cytoskeleton organization. When expressed in keratinocytes, induces changes in cell morphology with transfected cells showing an elongated shape, numerous membrane protrusions, and major reorganization of the actin cytoskeleton, increased motility and decreased cell adhesion. It requires for normal lung cell proliferation and alveolus formation at birth and Induces platelet aggregation. Nevertheless, it doesn’t have any effect on amino acid transport and the aquaporin-type water channels. |
Podoplanin Recombinant Protein |
91-788 |
ProSci |
0.05 mg |
EUR 490.25 |
Description: Podoplanin is a type-1 transmembrane protein that belongs to Podoplanin family. PDPN expressed in various specialized cell types throughout the body. It highly expressed in placenta, lung, skeletal muscle and brain, weakly expressed in brain, kidney and liver. In placenta, PDPN expressed on the apical plasma membrane of endothelium, in lung, expressed in alveolar epithelium. PDPN physiological function is related to its mucin-type character. PDPN may be involved in cell migration and/or actin cytoskeleton organization. When expressed in keratinocytes, induces changes in cell morphology with transfected cells showing an elongated shape, numerous membrane protrusions, and major reorganization of the actin cytoskeleton, increased motility and decreased cell adhesion. It requires for normal lung cell proliferation and alveolus formation at birth and Induces platelet aggregation. Nevertheless, it doesn’t have any effect on amino acid transport and the aquaporin-type water channels. |
Syrian Hamster Anti-Mouse Podoplanin (gp38) Monoclonal antibody, clone 8.1.1 |
CABT-L4294-1mg |
Creative Diagnostics |
1 mg |
EUR 897 |
Syrian Hamster Anti-Mouse Podoplanin (gp38) Monoclonal antibody, clone 8.1.1 |
CABT-L4294-5mg |
Creative Diagnostics |
5 mg |
EUR 2405 |
ELISA kit for Mouse PDPN (Podoplanin) |
E-EL-M2409 |
Elabscience Biotech |
1 plate of 96 wells |
EUR 534 |
|
Description: A sandwich ELISA kit for quantitative measurement of Mouse PDPN (Podoplanin) in samples from Serum, Plasma, Cell supernatant |
ELISA kit for Mouse Podoplanin (PDPN) |
KTE70775-48T |
Abbkine |
48T |
EUR 332 |
|
Description: Quantitative sandwich ELISA for measuring Mouse Podoplanin (PDPN) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
ELISA kit for Mouse Podoplanin (PDPN) |
KTE70775-5platesof96wells |
Abbkine |
5 plates of 96 wells |
EUR 2115 |
|
Description: Quantitative sandwich ELISA for measuring Mouse Podoplanin (PDPN) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
ELISA kit for Mouse Podoplanin (PDPN) |
KTE70775-96T |
Abbkine |
96T |
EUR 539 |
|
Description: Quantitative sandwich ELISA for measuring Mouse Podoplanin (PDPN) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
ELISA kit for Mouse PDPN (Podoplanin) |
ELK7080 |
ELK Biotech |
1 plate of 96 wells |
EUR 432 |
|
Description: A sandwich ELISA kit for detection of Podoplanin from Mouse in samples from blood, serum, plasma, cell culture fluid and other biological fluids. |
Podoplanin (PDPN) Polyclonal Antibody (Mouse), APC |
4-PAC719Mu01-APC |
Cloud-Clone |
-
EUR 351.00
-
EUR 3365.00
-
EUR 935.00
-
EUR 449.00
-
EUR 222.00
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
Description: A Rabbit polyclonal antibody against Mouse Podoplanin (PDPN). This antibody is labeled with APC. |