Development of Tomato bushy stunt virus-based vectors for fusion and non-fusion

Development of Tomato bushy stunt virus-based vectors for fusion and non-fusion expression of heterologous proteins in an alternative host Nicotiana excelsiana 

Plant virus-based expression systems are an alternative expression platform for the production of clinically and industrially useful recombinant proteins. Nonetheless, due to a lack of viral vector with the commercial potentials, it is urgent to design and develop new, versatile, and efficient plant virus vectors.

The genome of Tomato bushy stunt virus (TBSV) offers an attractive alternative to being modified as a vector for producing heterologous proteins in plants.

Here, we developed a set of novel fusion and non-fusion TBSV-CP replacement vectors, which provide more flexible and efficient tools for expressing proteins of interest in plants. An alternative tobacco plant, Nicotiana excelsiana, was used in this study as a host for newly constructed TBSV vectors because the unwanted necrotic effects were reported on the commonly used Nicotiana benthamiana host associated with expression of TBSV-encoded P19 protein.

The data showed that TBSV vectors caused a symptomless infection and overexpressed reporter gene in N. excelsiana leaves, demonstrating that N. excelsiana is an ideal host plant for TBSV-mediated heterologous gene expression. Moreover, a TBSV non-fusion vector, dAUG, shows the similar accumulation level of reporter proteins to that of TMV- and PVX-based vectors in side-by-side comparison and provides more flexible aspects than the previously developed TBSV vectors. Collectively, our newly developed TBSV expression system adds a new member to the family of plant viral expression vectors and meanwhile offers a flexible and highly effective approach for producing proteins of interest in plants.

 

KEY POINTS:

• The TBSV-based transient expression system has been significantly improved.

• The necrotic effects caused by viral P19 protein were avoided by the usage of N.   excelsiana as a host plant.

• The expression level of the non-fusion vector was similar to the most effective virus   vectors reported so far.

APC anti-human CD163
E16FHA163-025	EnoGene	25 tests	EUR 520
Description: Available in various conjugation types.

APC anti-human CD163
E16FHA163-100	EnoGene	100 tests	EUR 1191.67
Description: Available in various conjugation types.

FITC anti-human CD163
E16FHF163-025	EnoGene	25 tests	EUR 520
Description: Available in various conjugation types.

FITC anti-human CD163
E16FHF163-100	EnoGene	100 tests	EUR 1191.67
Description: Available in various conjugation types.

Biotin anti-human CD163
E16FHB163-025U	EnoGene	25 μg	EUR 346.67
Description: Available in various conjugation types.

Biotin anti-human CD163
E16FHB163-100U	EnoGene	100 μg	EUR 780
Description: Available in various conjugation types.

Purified anti-human CD163
E16FHU163-100U	EnoGene	100 μg	EUR 433.33
Description: Available in various conjugation types.

Recombinant Human CD163/CD163 Protein, His Tag
E40KMH346	EnoGene	20ug	EUR 495

Human CD163 Protein
E40KMPH6242	EnoGene	20ug	EUR 495

PE-Cy7 anti-human CD163
E16FHN163-025	EnoGene	25 tests	EUR 650
Description: Available in various conjugation types.

PE-Cy7 anti-human CD163
E16FHN163-100	EnoGene	100 tests	EUR 1408.33
Description: Available in various conjugation types.

Rabbit Anti Human CD163 Monoclonal Clone ABCC-3
IRBAHUCD163ABCC3C100UL	Innovative research	each	EUR 496
Description: Rabbit Anti Human CD163 Monoclonal Clone ABCC-3

APC-Cy7 anti-human CD163
E16FHO163-025	EnoGene	25 tests	EUR 650
Description: Available in various conjugation types.

APC-Cy7 anti-human CD163
E16FHO163-100	EnoGene	100 tests	EUR 1408.33
Description: Available in various conjugation types.

PerCP-Cy5.5 anti-human CD163
E16FHS163-025	EnoGene	25 tests	EUR 541.67
Description: Available in various conjugation types.

PerCP-Cy5.5 anti-human CD163
E16FHS163-100	EnoGene	100 tests	EUR 1278.33
Description: Available in various conjugation types.

anti- CD163/M130 Antibody
FNab09771	FN Test	100µg	EUR 658.5
Description: Antibody raised against CD163/M130

Anti-Hu CD163 PE
1P-645-T025	ExBio	25 tests	EUR 168

Anti-Hu CD163 PE
1P-645-T100	ExBio	100 tests	EUR 288

Anti-Hu CD163 APC
1A-645-T025	ExBio	25 tests	EUR 168

Anti-Hu CD163 APC
1A-645-T100	ExBio	100 tests	EUR 288

Anti-Hu CD163 Purified
11-645-C025	ExBio	0.025 mg	EUR 118.8

Anti-Hu CD163 Purified
11-645-C100	ExBio	0.1 mg	EUR 189.6

Human CD163, Fc Tag
E24PHA282	EnoGene	50 μg	EUR 250

Human CD163, His Tag
E24PHA281	EnoGene	50 μg	EUR 250

Human CD163 ELISA Kit
LF-EK50890	Abfrontier	1×96T	EUR 777.6

Human CD163 ELISA Kit
ELA-E1726h	Lifescience Market	96 Tests	EUR 988.8

Human CD163 shRNA Plasmid
20-abx956176	Abbexa	EUR 961.20 EUR 1345.20	150 µg 300 µg

CD163 (Human) ELISA Kit
EKA52023-5x96T	Biomatik Corporation	5x96T	Ask for price

CD163 (Human) ELISA Kit
EKA52023-96T	Biomatik Corporation	96T	EUR 446.9

Recombinant Human CD163 Protein
RP02295	Abclonal	500μg	EUR 1625

Human CellExp? CD163, Human recombinant
9226-10	Biovision	each	EUR 366

Human CellExp? CD163, Human recombinant
9226-50	Biovision	each	EUR 927.6

Anti-Hu CD163 PE-Cy7
T7-645-T025	ExBio	25 tests	EUR 184.8

Anti-Hu CD163 PE-Cy7
T7-645-T100	ExBio	100 tests	EUR 321.6

Anti-Hu CD163 PerCP-Cy5.5
T9-645-T025	ExBio	25 tests	EUR 235.2

Anti-Hu CD163 PerCP-Cy5.5
T9-645-T100	ExBio	100 tests	EUR 422.4

PE Anti-human CD163 Antibody *GHI/61*
116301K0	AAT Bioquest	25 tests	EUR 383
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

PE Anti-human CD163 Antibody *GHI/61*
116301K1	AAT Bioquest	100 tests	EUR 995
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

PE Anti-human CD163 Antibody *GHI/61*
116301K2	AAT Bioquest	500 tests	EUR 2984
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

PE Anti-human CD163 Antibody *GHI/61*
116301K0-25tests	AAT Bioquest	25 tests	EUR 383
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen.

PE Anti-human CD163 Antibody *GHI/61*
116301K1-100tests	AAT Bioquest	100 tests	EUR 995
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen.

PE Anti-human CD163 Antibody *GHI/61*
116301K2-500tests	AAT Bioquest	500 tests	EUR 2984
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen.

APC Anti-human CD163 Antibody *GHI/61*
116301B0	AAT Bioquest	25 tests	EUR 383
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

APC Anti-human CD163 Antibody *GHI/61*
116301B1	AAT Bioquest	100 tests	EUR 995
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

APC Anti-human CD163 Antibody *GHI/61*
116301B2	AAT Bioquest	500 tests	EUR 2984
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

APC Anti-human CD163 Antibody *GHI/61*
116301B0-25tests	AAT Bioquest	25 tests	EUR 383
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen.

APC Anti-human CD163 Antibody *GHI/61*
116301B1-100tests	AAT Bioquest	100 tests	EUR 995
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen.

APC Anti-human CD163 Antibody *GHI/61*
116301B2-500tests	AAT Bioquest	500 tests	EUR 2984
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen.

Alexa Fluor® 647 anti-human CD163
E16FHK163-025	EnoGene	25 tests	EUR 433.33
Description: Available in various conjugation types.

Alexa Fluor® 647 anti-human CD163
E16FHK163-100	EnoGene	100 tests	EUR 975
Description: Available in various conjugation types.

ELISA kit for Human CD163
EK5296	SAB	96 tests	EUR 663.6
Description: Enzyme-linked immunosorbent assay kit for quantification of Human CD163 in samples from serum, plasma, tissue homogenates and other biological fluids.

FITC Anti-human CD163 Antibody *GHI/61*
116301G0	AAT Bioquest	100 tests	EUR 547
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

FITC Anti-human CD163 Antibody *GHI/61*
116301G1	AAT Bioquest	500 tests	EUR 2051
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

FITC Anti-human CD163 Antibody *GHI/61*
116301G0-100tests	AAT Bioquest	100 tests	EUR 547
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen.

FITC Anti-human CD163 Antibody *GHI/61*
116301G1-500tests	AAT Bioquest	500 tests	EUR 2051
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen.

TRITC Anti-human CD163 Antibody *GHI/61*
116301H0	AAT Bioquest	100 tests	EUR 547
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

TRITC Anti-human CD163 Antibody *GHI/61*
116301H1	AAT Bioquest	500 tests	EUR 2051
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

PerCP Anti-human CD163 Antibody *GHI/61*
116301S0	AAT Bioquest	25 tests	EUR 383
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

PerCP Anti-human CD163 Antibody *GHI/61*
116301S1	AAT Bioquest	100 tests	EUR 995
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

PerCP Anti-human CD163 Antibody *GHI/61*
116301S2	AAT Bioquest	500 tests	EUR 2984
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

TRITC Anti-human CD163 Antibody *GHI/61*
116301H0-100tests	AAT Bioquest	100 tests	EUR 547
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen.

TRITC Anti-human CD163 Antibody *GHI/61*
116301H1-500tests	AAT Bioquest	500 tests	EUR 2051
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen.

PerCP Anti-human CD163 Antibody *GHI/61*
116301S0-25tests	AAT Bioquest	25 tests	EUR 383
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen.

PerCP Anti-human CD163 Antibody *GHI/61*
116301S1-100tests	AAT Bioquest	100 tests	EUR 995
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen.

PerCP Anti-human CD163 Antibody *GHI/61*
116301S2-500tests	AAT Bioquest	500 tests	EUR 2984
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen.

Human CD163 Protein, His Tag
CD3-H52E8	ACROBIOSYSTEMS	1mg	EUR 374.5
Description: Human CD163, His Tag (CD3-H52E8) is expressed from human 293 cells (HEK293). It contains AA Ser 42 - Ser 1045 (Accession # Q86VB7).

Canine CD163 antigen(CD163 LISA kit
GA-E0062CN-48T	GenAsia Biotech	48T	EUR 482.4

Canine CD163 antigen(CD163 LISA kit
GA-E0062CN-96T	GenAsia Biotech	96T	EUR 820.8

PacBlue Anti-human CD163 Antibody *GHI/61*
116301I0	AAT Bioquest	100 tests	EUR 547
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

PacBlue Anti-human CD163 Antibody *GHI/61*
116301I1	AAT Bioquest	500 tests	EUR 2051
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

PacBlue Anti-human CD163 Antibody *GHI/61*
116301I0-100tests	AAT Bioquest	100 tests	EUR 547
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen.

PacBlue Anti-human CD163 Antibody *GHI/61*
116301I1-500tests	AAT Bioquest	500 tests	EUR 2051
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen.

Porcine CD163 antigen,CD163 LISA kit
GA-E0045PC-48T	GenAsia Biotech	48T	EUR 436.8

Porcine CD163 antigen,CD163 LISA kit
GA-E0045PC-96T	GenAsia Biotech	96T	EUR 708

Porcine CD163 antigen,CD163 LISA kit
YLA0139PO-48T	Shanghai YL Biotech	48T	EUR 502.5

Porcine CD163 antigen,CD163 LISA kit
YLA0139PO-96T	Shanghai YL Biotech	96T	EUR 618.75

Purified Anti-human CD163 Antibody *GHI/61*
11630000	AAT Bioquest	100 ug	EUR 365
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

Purified Anti-human CD163 Antibody *GHI/61*
11630000-100ug	AAT Bioquest	100 ug	EUR 365
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen.

PacOrange Anti-human CD163 Antibody *GHI/61*
116301J0	AAT Bioquest	100 tests	EUR 547
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

PacOrange Anti-human CD163 Antibody *GHI/61*
116301J1	AAT Bioquest	500 tests	EUR 2051
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

PacOrange Anti-human CD163 Antibody *GHI/61*
116301J0-100tests	AAT Bioquest	100 tests	EUR 547
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen.

PacOrange Anti-human CD163 Antibody *GHI/61*
116301J1-500tests	AAT Bioquest	500 tests	EUR 2051
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen.

Human CD163 PicoKine ELISA Kit
EK0715	BosterBio	96 wells	EUR 510
Description: For quantitative detection of human CD163 in cell culture supernates, serum and plasma(heparin).

Human CD163 Protein Lysate 20ug
IHUCD163PLLY20UG	Innovative research	each	EUR 213
Description: Human CD163 Protein Lysate 20ug

CD163 Antibody
20-abx242956	Abbexa	EUR 560.40 EUR 393.60	100 ul 50 ul

CD163 antibody
10R-6496	Fitzgerald	100 ug	EUR 243.6
Description: Mouse monoclonal CD163 antibody

CD163 antibody
10R-CD163aRT	Fitzgerald	250 ug	EUR 859.2
Description: Mouse monoclonal CD163 antibody

CD163 Antibody
37157-100ul	SAB	100ul	EUR 302.4

CD163 Antibody
49553-100ul	SAB	100ul	EUR 399.6

CD163 Antibody
49553-50ul	SAB	50ul	EUR 286.8

CD163 Antibody
ABD8235	Lifescience Market	100 ug	EUR 525.6

CD163 Antibody
1-CSB-PA969205	Cusabio	EUR 380.40 EUR 292.80	100ul 50ul
Description: A polyclonal antibody against CD163. Recognizes CD163 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:1000-1:2000, IHC:1:25-1:100

CD163 Antibody
1-CSB-PA801238LA01HU	Cusabio	EUR 380.40 EUR 402.00	100ul 50ul
Description: A polyclonal antibody against CD163. Recognizes CD163 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IF; Recommended dilution: IF:1:50-1:200

Cd163 Antibody
1-CSB-PA650452LA01MO	Cusabio	EUR 380.40 EUR 402.00	100ug 50ug
Description: A polyclonal antibody against Cd163. Recognizes Cd163 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB; Recommended dilution: WB:1:500-1:2000

CD163 Antibody
F50316-0.4ML	NSJ Bioreagents	0.4 ml	EUR 322.15
Description: CD163 is an acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. The protein may play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. It binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. And it exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. It also induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1.

CD163 Antibody
F50316-0.08ML	NSJ Bioreagents	0.08 ml	EUR 140.25
Description: CD163 is an acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. The protein may play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. It binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. And it exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. It also induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1.

CD163 Antibody
RQ4259	NSJ Bioreagents	100 ug	EUR 356.15
Description: CD163 (Cluster of Differentiation 163) is a protein that in humans is encoded by the CD163 gene. The protein encoded by this gene is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. It functions as an acute phase-regulated receptor involved in the clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages, and may thereby protect tissues from free hemoglobin-mediated oxidative damage. This protein may also function as an innate immune sensor for bacteria and inducer of local inflammation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

CD163 Antibody
V7470-100UG	NSJ Bioreagents	100 ug	EUR 349.3
Description: This antibody recognizes a protein of 140kDa, identified as CD163. It has been identified as an acute phase-regulated transmembrane protein whose function is to mediate the endocytosis of haptoglobin-hemoglobin complexes. This receptor is expressed on the surface of monocytes with low expression and on tissue macrophages, histiocytes with high expression. Staining with anti-CD163 has been helpful to distinguish synovial macrophages from synovial intimal fibroblasts in rheumatoid arthritis, where its specificity for macrophages was found to be superior to that of anti-CD68. Increased levels of CD163 were also detected in patients with microbial infections and myelomonocytic leukemias. Anti-CD163 is of considerable value for selective identification of monocytes and macrophages at a certain stage of differentiation and is suitable for diagnosing myelomonocytic or monocytic leukaemia and neoplasms of true histiocytic origin. CD163 is positive in skin (histiocytes), gut, Kupffer cells, a few alveolar macrophages, macrophages in the placenta, and in macrophages in inflamed tissues including tumor tissue.

CD163 Antibody
V7470-20UG	NSJ Bioreagents	20 ug	EUR 153.3
Description: This antibody recognizes a protein of 140kDa, identified as CD163. It has been identified as an acute phase-regulated transmembrane protein whose function is to mediate the endocytosis of haptoglobin-hemoglobin complexes. This receptor is expressed on the surface of monocytes with low expression and on tissue macrophages, histiocytes with high expression. Staining with anti-CD163 has been helpful to distinguish synovial macrophages from synovial intimal fibroblasts in rheumatoid arthritis, where its specificity for macrophages was found to be superior to that of anti-CD68. Increased levels of CD163 were also detected in patients with microbial infections and myelomonocytic leukemias. Anti-CD163 is of considerable value for selective identification of monocytes and macrophages at a certain stage of differentiation and is suitable for diagnosing myelomonocytic or monocytic leukaemia and neoplasms of true histiocytic origin. CD163 is positive in skin (histiocytes), gut, Kupffer cells, a few alveolar macrophages, macrophages in the placenta, and in macrophages in inflamed tissues including tumor tissue.

CD163 Antibody
V7470IHC-7ML	NSJ Bioreagents	7 ml	EUR 349.3
Description: This antibody recognizes a protein of 140kDa, identified as CD163. It has been identified as an acute phase-regulated transmembrane protein whose function is to mediate the endocytosis of haptoglobin-hemoglobin complexes. This receptor is expressed on the surface of monocytes with low expression and on tissue macrophages, histiocytes with high expression. Staining with anti-CD163 has been helpful to distinguish synovial macrophages from synovial intimal fibroblasts in rheumatoid arthritis, where its specificity for macrophages was found to be superior to that of anti-CD68. Increased levels of CD163 were also detected in patients with microbial infections and myelomonocytic leukemias. Anti-CD163 is of considerable value for selective identification of monocytes and macrophages at a certain stage of differentiation and is suitable for diagnosing myelomonocytic or monocytic leukaemia and neoplasms of true histiocytic origin. CD163 is positive in skin (histiocytes), gut, Kupffer cells, a few alveolar macrophages, macrophages in the placenta, and in macrophages in inflamed tissues including tumor tissue.

CD163 Antibody
V7470SAF-100UG	NSJ Bioreagents	100 ug	EUR 349.3
Description: This antibody recognizes a protein of 140kDa, identified as CD163. It has been identified as an acute phase-regulated transmembrane protein whose function is to mediate the endocytosis of haptoglobin-hemoglobin complexes. This receptor is expressed on the surface of monocytes with low expression and on tissue macrophages, histiocytes with high expression. Staining with anti-CD163 has been helpful to distinguish synovial macrophages from synovial intimal fibroblasts in rheumatoid arthritis, where its specificity for macrophages was found to be superior to that of anti-CD68. Increased levels of CD163 were also detected in patients with microbial infections and myelomonocytic leukemias. Anti-CD163 is of considerable value for selective identification of monocytes and macrophages at a certain stage of differentiation and is suitable for diagnosing myelomonocytic or monocytic leukaemia and neoplasms of true histiocytic origin. CD163 is positive in skin (histiocytes), gut, Kupffer cells, a few alveolar macrophages, macrophages in the placenta, and in macrophages in inflamed tissues including tumor tissue.

CD163 Antibody
V8227-100UG	NSJ Bioreagents	100 ug	EUR 349.3
Description: This MAb recognizes a protein of 140kDa, identified as CD163. It has been identified as an acute phase-regulated transmembrane protein whose function is to mediate the endocytosis of haptoglobin-hemoglobin complexes. This receptor is expressed on the surface of monocytes with low expression and on tissue macrophages, histiocytes with high expression. Staining with anti-CD163 has been helpful to distinguish synovial macrophages from synovial intimal fibroblasts in rheumatoid arthritis, where its specificity for macrophages was found to be superior to that of anti-CD68. Increased levels of CD163 were also detected in patients with microbial infections and myelomonocytic leukemias. Anti-CD163 is of considerable value for selective identification of monocytes and macrophages at a certain stage of differentiation and is suitable for diagnosing myelomonocytic or monocytic leukaemia and neoplasms of true histiocytic origin. CD163 is positive in skin (histiocytes), gut, Kupffer cells, a few alveolar macrophages, macrophages in the placenta, and in macrophages in inflamed tissues including tumor tissue.

CD163 Antibody
V8227-20UG	NSJ Bioreagents	20 ug	EUR 153.3
Description: This MAb recognizes a protein of 140kDa, identified as CD163. It has been identified as an acute phase-regulated transmembrane protein whose function is to mediate the endocytosis of haptoglobin-hemoglobin complexes. This receptor is expressed on the surface of monocytes with low expression and on tissue macrophages, histiocytes with high expression. Staining with anti-CD163 has been helpful to distinguish synovial macrophages from synovial intimal fibroblasts in rheumatoid arthritis, where its specificity for macrophages was found to be superior to that of anti-CD68. Increased levels of CD163 were also detected in patients with microbial infections and myelomonocytic leukemias. Anti-CD163 is of considerable value for selective identification of monocytes and macrophages at a certain stage of differentiation and is suitable for diagnosing myelomonocytic or monocytic leukaemia and neoplasms of true histiocytic origin. CD163 is positive in skin (histiocytes), gut, Kupffer cells, a few alveolar macrophages, macrophages in the placenta, and in macrophages in inflamed tissues including tumor tissue.

CD163 Antibody
V8227SAF-100UG	NSJ Bioreagents	100 ug	EUR 349.3
Description: This MAb recognizes a protein of 140kDa, identified as CD163. It has been identified as an acute phase-regulated transmembrane protein whose function is to mediate the endocytosis of haptoglobin-hemoglobin complexes. This receptor is expressed on the surface of monocytes with low expression and on tissue macrophages, histiocytes with high expression. Staining with anti-CD163 has been helpful to distinguish synovial macrophages from synovial intimal fibroblasts in rheumatoid arthritis, where its specificity for macrophages was found to be superior to that of anti-CD68. Increased levels of CD163 were also detected in patients with microbial infections and myelomonocytic leukemias. Anti-CD163 is of considerable value for selective identification of monocytes and macrophages at a certain stage of differentiation and is suitable for diagnosing myelomonocytic or monocytic leukaemia and neoplasms of true histiocytic origin. CD163 is positive in skin (histiocytes), gut, Kupffer cells, a few alveolar macrophages, macrophages in the placenta, and in macrophages in inflamed tissues including tumor tissue.

CD163 Antibody
V8415-100UG	NSJ Bioreagents	100 ug	EUR 349.3
Description: This MAb recognizes a protein of 140kDa, identified as CD163. It has been identified as an acute phase-regulated transmembrane protein whose function is to mediate the endocytosis of haptoglobin-hemoglobin complexes. This receptor is expressed on the surface of monocytes with low expression and on tissue macrophages, histiocytes with high expression. Staining with anti-CD163 has been helpful to distinguish synovial macrophages from synovial intimal fibroblasts in rheumatoid arthritis, where its specificity for macrophages was found to be superior to that of anti-CD68. Increased levels of CD163 were also detected in patients with microbial infections and myelomonocytic leukemias. Anti-CD163 is of considerable value for selective identification of monocytes and macrophages at a certain stage of differentiation and is suitable for diagnosing myelomonocytic or monocytic leukaemia and neoplasms of true histiocytic origin. CD163 is positive in skin (histiocytes), gut, Kupffer cells, a few alveolar macrophages, macrophages in the placenta, and in macrophages in inflamed tissues including tumor tissue.

CD163 Antibody
V8415-20UG	NSJ Bioreagents	20 ug	EUR 153.3
Description: This MAb recognizes a protein of 140kDa, identified as CD163. It has been identified as an acute phase-regulated transmembrane protein whose function is to mediate the endocytosis of haptoglobin-hemoglobin complexes. This receptor is expressed on the surface of monocytes with low expression and on tissue macrophages, histiocytes with high expression. Staining with anti-CD163 has been helpful to distinguish synovial macrophages from synovial intimal fibroblasts in rheumatoid arthritis, where its specificity for macrophages was found to be superior to that of anti-CD68. Increased levels of CD163 were also detected in patients with microbial infections and myelomonocytic leukemias. Anti-CD163 is of considerable value for selective identification of monocytes and macrophages at a certain stage of differentiation and is suitable for diagnosing myelomonocytic or monocytic leukaemia and neoplasms of true histiocytic origin. CD163 is positive in skin (histiocytes), gut, Kupffer cells, a few alveolar macrophages, macrophages in the placenta, and in macrophages in inflamed tissues including tumor tissue.

CD163 Antibody
V8415SAF-100UG	NSJ Bioreagents	100 ug	EUR 349.3
Description: This MAb recognizes a protein of 140kDa, identified as CD163. It has been identified as an acute phase-regulated transmembrane protein whose function is to mediate the endocytosis of haptoglobin-hemoglobin complexes. This receptor is expressed on the surface of monocytes with low expression and on tissue macrophages, histiocytes with high expression. Staining with anti-CD163 has been helpful to distinguish synovial macrophages from synovial intimal fibroblasts in rheumatoid arthritis, where its specificity for macrophages was found to be superior to that of anti-CD68. Increased levels of CD163 were also detected in patients with microbial infections and myelomonocytic leukemias. Anti-CD163 is of considerable value for selective identification of monocytes and macrophages at a certain stage of differentiation and is suitable for diagnosing myelomonocytic or monocytic leukaemia and neoplasms of true histiocytic origin. CD163 is positive in skin (histiocytes), gut, Kupffer cells, a few alveolar macrophages, macrophages in the placenta, and in macrophages in inflamed tissues including tumor tissue.

CD163 Antibody
V8757-100UG	NSJ Bioreagents	100 ug	EUR 349.3
Description: CD163 is a type I membrane protein, and is a member of the hemoglobin scavenger receptor cystein-rich superfamily. The protein is involved in the clearance of hemoglobin-haptoglobin complexes and is considered to have anti-inflammatory functions. CD163 expression is restricted to the monocytic/macrophage lineage. It is expressed by all circulating monocytes and by a majority of tissue macrophages, such as splenic dendrocytes, alveolar macrophages and Kupffer cells of the liver. It is not present in macrophages in the mantle zone and some of the germinal center cells in lymph follicles, nor in Langerhans cells and interdigitating reticulum cells. In tumor tissues, CD163 is found in almost all cases of acute myeloid leukemia with monocytoid differentiation and in the majority of cases of histiocytic sarcoma, littoral cell angioma, Rosai-Dorfman disease, Langerhans cell histiocytosis and typical and atypical fibrous histiocytoma. It is also expressed in some cases of dermatofibrosarcoma protuberans. CD163 can be used to detect cells of monocytic and histiocyte lineage in neoplastic and reactive lesions. It has been shown to be more sensitive than CD68 for the detection of macrophages and monocytic cells. It covers a similar, but not identical, spectrum of cells as CD68.

CD163 Antibody
V8757-20UG	NSJ Bioreagents	20 ug	EUR 153.3
Description: CD163 is a type I membrane protein, and is a member of the hemoglobin scavenger receptor cystein-rich superfamily. The protein is involved in the clearance of hemoglobin-haptoglobin complexes and is considered to have anti-inflammatory functions. CD163 expression is restricted to the monocytic/macrophage lineage. It is expressed by all circulating monocytes and by a majority of tissue macrophages, such as splenic dendrocytes, alveolar macrophages and Kupffer cells of the liver. It is not present in macrophages in the mantle zone and some of the germinal center cells in lymph follicles, nor in Langerhans cells and interdigitating reticulum cells. In tumor tissues, CD163 is found in almost all cases of acute myeloid leukemia with monocytoid differentiation and in the majority of cases of histiocytic sarcoma, littoral cell angioma, Rosai-Dorfman disease, Langerhans cell histiocytosis and typical and atypical fibrous histiocytoma. It is also expressed in some cases of dermatofibrosarcoma protuberans. CD163 can be used to detect cells of monocytic and histiocyte lineage in neoplastic and reactive lesions. It has been shown to be more sensitive than CD68 for the detection of macrophages and monocytic cells. It covers a similar, but not identical, spectrum of cells as CD68.

CD163 Antibody
V8757SAF-100UG	NSJ Bioreagents	100 ug	EUR 349.3
Description: CD163 is a type I membrane protein, and is a member of the hemoglobin scavenger receptor cystein-rich superfamily. The protein is involved in the clearance of hemoglobin-haptoglobin complexes and is considered to have anti-inflammatory functions. CD163 expression is restricted to the monocytic/macrophage lineage. It is expressed by all circulating monocytes and by a majority of tissue macrophages, such as splenic dendrocytes, alveolar macrophages and Kupffer cells of the liver. It is not present in macrophages in the mantle zone and some of the germinal center cells in lymph follicles, nor in Langerhans cells and interdigitating reticulum cells. In tumor tissues, CD163 is found in almost all cases of acute myeloid leukemia with monocytoid differentiation and in the majority of cases of histiocytic sarcoma, littoral cell angioma, Rosai-Dorfman disease, Langerhans cell histiocytosis and typical and atypical fibrous histiocytoma. It is also expressed in some cases of dermatofibrosarcoma protuberans. CD163 can be used to detect cells of monocytic and histiocyte lineage in neoplastic and reactive lesions. It has been shown to be more sensitive than CD68 for the detection of macrophages and monocytic cells. It covers a similar, but not identical, spectrum of cells as CD68.

CD163 Antibody
R20390-0.1ML	NSJ Bioreagents	100ul	EUR 409

CD163 Antibody
DF8235	Affinity Biosciences	100ul	EUR 280
Description: Human,Mouse,Rat

CD163 Antibody
R30973	NSJ Bioreagents	100 ug	EUR 356.15
Description: CD163 (Cluster of Differentiation 163) is a human protein encoded by the CD163 gene. The receptor belongs to the scavenger receptor cysteine rich family type B and consists of an 1048 amino acid residues extracellular domain, a single transmembrane segment and a cytoplasmic tail with several splice variants. CD163 is a scavenger receptor for the hemoglobin-haptoglobincomplex. Using FISH, somatic cell hybrid analysis, and radiation hybrid analysis, Stover et al.(2000) mapped the CD163 gene to chromosome 12p13.3. Specific CD163-mediated endocytosis of haptoglobin-hemoglobin complexes was measurable in cells transfected with CD163 cDNA and in CD163-expressing myelomonocytic lymphoma cells.CD163 expression in monocytes promoted bacteria-induced proinflammatory cytokine production that could be blocked by anti-CD163 antibodies. Cells expressing human CD163 and recombinant protein containing the extracellular domain of CD163 supported adhesion of erythroblastic cells.

CD163 Antibody
R30974	NSJ Bioreagents	100 ug	EUR 356.15
Description: Cluster of Differentiation 163, also known as Hemoglobin scavenger receptor, is a human protein encoded by the CD163 gene. The receptor belongs to the scavenger receptor cysteine rich family type B and consists of an 1048 amino acid residues extracellular domain, a single transmembrane segment and a cytoplasmic tail with several splice variants. CD163 is a scavenger receptorfor the hemoglobin-haptoglobin complex. Using FISH, somatic cell hybrid analysis, and radiation hybrid analysis, Stover et al.(2000) mapped the gene to chromosome 12p13.3. CD163 expression in monocytes promoted bacteria-induced proinflammatory cytokine production that could be blocked by CD163 antibody. Cells expressing human CD163 and recombinant protein containing the extracellular domain of CD163 supported adhesion of erythroblastic cells.

CD163 Antibody
V3937-100UG	NSJ Bioreagents	100 ug	EUR 349.3
Description: This antibody recognizes a protein of 140kDa, identified as CD163. It has been identified as an acute phase-regulated transmembrane protein whose function is to mediate the endocytosis of haptoglobin-hemoglobin complexes. This receptor is expressed on the surface of monocytes with low expression and on tissue macrophages, histiocytes with high expression. Staining with anti-CD163 has been helpful to distinguish synovial macrophages from synovial intimal fibroblasts in rheumatoid arthritis, where its specificity for macrophages was found to be superior to that of anti-CD68. Increased levels of CD163 were also detected in patients with microbial infections and myelomonocytic leukemias. Anti-CD163 is of considerable value for selective identification of monocytes and macrophages at a certain stage of differentiation and is suitable for diagnosing myelomonocytic or monocytic leukaemia and neoplasms of true histiocytic origin. CD163 is positive in skin (histiocytes), gut, Kupffer cells, a few alveolar macrophages, macrophages in the placenta, and in macrophages in inflamed tissues including tumor tissue.

CD163 Antibody
V3937-20UG	NSJ Bioreagents	20 ug	EUR 153.3
Description: This antibody recognizes a protein of 140kDa, identified as CD163. It has been identified as an acute phase-regulated transmembrane protein whose function is to mediate the endocytosis of haptoglobin-hemoglobin complexes. This receptor is expressed on the surface of monocytes with low expression and on tissue macrophages, histiocytes with high expression. Staining with anti-CD163 has been helpful to distinguish synovial macrophages from synovial intimal fibroblasts in rheumatoid arthritis, where its specificity for macrophages was found to be superior to that of anti-CD68. Increased levels of CD163 were also detected in patients with microbial infections and myelomonocytic leukemias. Anti-CD163 is of considerable value for selective identification of monocytes and macrophages at a certain stage of differentiation and is suitable for diagnosing myelomonocytic or monocytic leukaemia and neoplasms of true histiocytic origin. CD163 is positive in skin (histiocytes), gut, Kupffer cells, a few alveolar macrophages, macrophages in the placenta, and in macrophages in inflamed tissues including tumor tissue.

CD163 Antibody
V3937SAF-100UG	NSJ Bioreagents	100 ug	EUR 349.3
Description: This antibody recognizes a protein of 140kDa, identified as CD163. It has been identified as an acute phase-regulated transmembrane protein whose function is to mediate the endocytosis of haptoglobin-hemoglobin complexes. This receptor is expressed on the surface of monocytes with low expression and on tissue macrophages, histiocytes with high expression. Staining with anti-CD163 has been helpful to distinguish synovial macrophages from synovial intimal fibroblasts in rheumatoid arthritis, where its specificity for macrophages was found to be superior to that of anti-CD68. Increased levels of CD163 were also detected in patients with microbial infections and myelomonocytic leukemias. Anti-CD163 is of considerable value for selective identification of monocytes and macrophages at a certain stage of differentiation and is suitable for diagnosing myelomonocytic or monocytic leukaemia and neoplasms of true histiocytic origin. CD163 is positive in skin (histiocytes), gut, Kupffer cells, a few alveolar macrophages, macrophages in the placenta, and in macrophages in inflamed tissues including tumor tissue.

CD163 Antibody
E037157	EnoGene	100μg/100μl	EUR 255
Description: Available in various conjugation types.

CD163 Antibody
E19-8235-1	EnoGene	50ug/50ul	EUR 145
Description: Available in various conjugation types.

CD163 Antibody
E19-8235-2	EnoGene	100ug/100ul	EUR 225
Description: Available in various conjugation types.

CD163 Antibody
E38PA9656	EnoGene	100ul	EUR 225
Description: Available in various conjugation types.

CD163 Antibody
E39-10799	EnoGene	100ug/100ul	EUR 225
Description: Available in various conjugation types.

CD163 Antibody
DF8235-100ul	Affinity Biosciences	100ul	EUR 280

CD163 Antibody
DF8235-200ul	Affinity Biosciences	200ul	EUR 350

CD163 ORF Vector (Human) (pORF)
ORF017045	ABM	1.0 ug DNA	EUR 486

CD163 ELISA Kit (Human) (OKBB00786)
OKBB00786	Aviva Systems Biology	96 Wells	EUR 606
Description: Description of target: CD163(Cluster of Differentiation 163) is a human protein encoded by the CD163 gene. It has also been shown to mark cells of monocyte/macrophage lineage. CD163, a member of the scavenger receptor cysteine-rich(SRCR) superfamily, is exclusively expressed by monocytes and macrophages. Using FISH, somatic cell hybrid analysis, and radiation hybrid analysis, CD163 gene was mapped the to chromosome 12p13.3. CD163 is upregulated in a large range of diseases inflammatory diseases including type 2 diabetes, macrophage activation sickness, Tangier's disease, reumatoid arthritis etc.;Species reactivity: Human;Application: ELISA;Assay info: ;Sensitivity: <150pg/ml

CD163 ELISA Kit (Human) (OKAN04666)
OKAN04666	Aviva Systems Biology	96 Wells	EUR 950.4
Description: Description of target: The protein encoded by this gene is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. It functions as an acute phase-regulated receptor involved in the clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages, and may thereby protect tissues from free hemoglobin-mediated oxidative damage. This protein may also function as an innate immune sensor for bacteria and inducer of local inflammation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.273 ng/mL

CD163 ELISA Kit (Human) (OKBB01513)
OKBB01513	Aviva Systems Biology	96 Wells	EUR 684
Description: Description of target: CD163(Cluster of Differentiation 163) is a human protein encoded by the CD163 gene. It has also been shown to mark cells of monocyte/macrophage lineage. CD163, a member of the scavenger receptor cysteine-rich(SRCR) superfamily, is exclusively expressed by monocytes and macrophages. Using FISH, somatic cell hybrid analysis, and radiation hybrid analysis, CD163 gene was mapped the to chromosome 12p13.3. CD163 is upregulated in a large range of diseases inflammatory diseases including type 2 diabetes, macrophage activation sickness, Tangier's disease, reumatoid arthritis etc.;Species reactivity: Human;Application: ELISA;Assay info: ;Sensitivity: <150pg/ml

CD163 ELISA Kit (Human) (OKCD07621)
OKCD07621	Aviva Systems Biology	96 Wells	EUR 1123.2
Description: Description of target: The protein encoded by this gene is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. It functions as an acute phase-regulated receptor involved in the clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages, and may thereby protect tissues from free hemoglobin-mediated oxidative damage. This protein may also function as an innate immune sensor for bacteria and inducer of local inflammation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.;Species reactivity: Human;Application: ELISA;Assay info: ;Sensitivity: < 0.273ng/mL

CD163
pro-2496	ProSpec Tany	1µg	EUR 60
Description: Recombinant Human CD163

CD163
E8ET1704-43	EnoGene	100ul	EUR 275
Description: Available in various conjugation types.

CD163
E8ER1804-03	EnoGene	100ul	EUR 275
Description: Available in various conjugation types.

QuickDetect? CD163 (Human) ELISA Kit
K4422-100	Biovision	each	EUR 966

PE/Cy5 Anti-human CD163 Antibody *GHI/61*
116301L0	AAT Bioquest	25 tests	EUR 429
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

PE/Cy5 Anti-human CD163 Antibody *GHI/61*
116301L1	AAT Bioquest	100 tests	EUR 1117
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

PE/Cy5 Anti-human CD163 Antibody *GHI/61*
116301L2	AAT Bioquest	500 tests	EUR 3351
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

PE/Cy7 Anti-human CD163 Antibody *GHI/61*
116301M0	AAT Bioquest	25 tests	EUR 429
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

PE/Cy7 Anti-human CD163 Antibody *GHI/61*
116301M1	AAT Bioquest	100 tests	EUR 1117
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

PE/Cy7 Anti-human CD163 Antibody *GHI/61*
116301M2	AAT Bioquest	500 tests	EUR 3351
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

PE/Cy5 Anti-human CD163 Antibody *GHI/61*
116301L0-25tests	AAT Bioquest	25 tests	EUR 429
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen.

PE/Cy5 Anti-human CD163 Antibody *GHI/61*
116301L1-100tests	AAT Bioquest	100 tests	EUR 1117
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen.

PE/Cy5 Anti-human CD163 Antibody *GHI/61*
116301L2-500tests	AAT Bioquest	500 tests	EUR 3351
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen.

PE/Cy7 Anti-human CD163 Antibody *GHI/61*
116301M0-25tests	AAT Bioquest	25 tests	EUR 429
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen.

PE/Cy7 Anti-human CD163 Antibody *GHI/61*
116301M1-100tests	AAT Bioquest	100 tests	EUR 1117
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen.

PE/Cy7 Anti-human CD163 Antibody *GHI/61*
116301M2-500tests	AAT Bioquest	500 tests	EUR 3351
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen.

APC/Cy7 Anti-human CD163 Antibody *GHI/61*
116301C0	AAT Bioquest	25 tests	EUR 429
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

APC/Cy7 Anti-human CD163 Antibody *GHI/61*
116301C1	AAT Bioquest	100 tests	EUR 1117
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

APC/Cy7 Anti-human CD163 Antibody *GHI/61*
116301C2	AAT Bioquest	500 tests	EUR 3351
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

APC/Cy7 Anti-human CD163 Antibody *GHI/61*
116301C0-25tests	AAT Bioquest	25 tests	EUR 429
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen.

APC/Cy7 Anti-human CD163 Antibody *GHI/61*
116301C1-100tests	AAT Bioquest	100 tests	EUR 1117
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen.

APC/Cy7 Anti-human CD163 Antibody *GHI/61*
116301C2-500tests	AAT Bioquest	500 tests	EUR 3351
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen.

Nori® Human CD163 ELISA Kit
GR111545	Genorise Scientific	96-well	EUR 461

PerCP/Cy5.5 Anti-human CD163 Antibody *GHI/61*
116301T0	AAT Bioquest	25 tests	EUR 429
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

PerCP/Cy5.5 Anti-human CD163 Antibody *GHI/61*
116301T1	AAT Bioquest	100 tests	EUR 1117
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

PerCP/Cy5.5 Anti-human CD163 Antibody *GHI/61*
116301T2	AAT Bioquest	500 tests	EUR 3351
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

PerCP/Cy5.5 Anti-human CD163 Antibody *GHI/61*
116301T0-25tests	AAT Bioquest	25 tests	EUR 429
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen.

PerCP/Cy5.5 Anti-human CD163 Antibody *GHI/61*
116301T1-100tests	AAT Bioquest	100 tests	EUR 1117
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen.

PerCP/Cy5.5 Anti-human CD163 Antibody *GHI/61*
116301T2-500tests	AAT Bioquest	500 tests	EUR 3351
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen.

Mouse Anti Rat Cd163 Monoclonal Antibody
DMABT-47170MR	Creative Diagnostics	0.25 mg	EUR 889.2

Mouse Anti Rat Cd163 Monoclonal Antibody
DMABT-47171MR	Creative Diagnostics	0.1 mg	EUR 670.8

Anti-Human CD163 DyLight® 488 conjugated Antibody
A00812-Dyl488	BosterBio	100ug/vial	EUR 412.8

Anti-Human CD163 DyLight® 550 conjugated Antibody
A00812-Dyl550	BosterBio	100ug/vial	EUR 412.8

Mouse Anti-Human CD163 monoclonal antibody, clone JID274
CABT-L2938-100uL500uL	Creative Diagnostics	100 uL, 500 uL	EUR 602.4

CD163 (ABT-CD163) Mouse mAb
E2252704	EnoGene	100ul	EUR 225
Description: Available in various conjugation types.

Human soluble CD163(sCD163) ELISA Kit
1-CSB-E14050h	Cusabio	EUR 952.80 EUR 6033.60 EUR 3200.40	1 plate of 96 wells 10 plates of 96 wells each 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Human soluble CD163(sCD163) in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Human soluble CD163(sCD163) ELISA Kit
CSB-E14050h-24T	Cusabio	1 plate of 24 wells	EUR 198
Description: Quantitativesandwich ELISA kit for measuring Human soluble CD163 (sCD163) in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Human Soluble CD163 (sCD163) ELISA Kit
KTE62428-96T5	Abbkine	96 T×5	EUR 2629
Description: This Human Soluble CD163 (sCD163) ELISA Kit employs a two-site sandwich ELISA to quantitate CD163.

Human Soluble CD163 (sCD163) ELISA Kit
KTE62428-96T50	Abbkine	96 T×50	EUR 24569
Description: This Human Soluble CD163 (sCD163) ELISA Kit employs a two-site sandwich ELISA to quantitate CD163.

Human soluble CD163(sCD163) ELISA Kit
EKC35589-48T	Biomatik Corporation	48T	EUR 528.43

Human soluble CD163(sCD163) ELISA Kit
EKC35589-5x96T	Biomatik Corporation	5x96T	EUR 3585.78

Human soluble CD163(sCD163) ELISA Kit
EKC35589-96T	Biomatik Corporation	96T	EUR 754.9

Human soluble CD163 (sCD163)ELISA Kit
YLA0777HU-48T	Shanghai YL Biotech	48T	EUR 435

Human soluble CD163 (sCD163)ELISA Kit
YLA0777HU-96T	Shanghai YL Biotech	96T	EUR 562.5

Human soluble CD163(sCD163) ELISA Kit
SL2931Hu	Sunlong	96 Tests	EUR 468

CD163 antibody (PE)
61R-1319	Fitzgerald	100 tests	EUR 483.6
Description: Mouse monoclonal CD163 antibody (PE)

iFluor® 350 Anti-human CD163 Antibody *GHI/61*
11630010	AAT Bioquest	100 tests	EUR 547
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

iFluor® 350 Anti-human CD163 Antibody *GHI/61*
11630011	AAT Bioquest	500 tests	EUR 2051
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

iFluor® 405 Anti-human CD163 Antibody *GHI/61*
11630020	AAT Bioquest	100 tests	EUR 547
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

iFluor® 405 Anti-human CD163 Antibody *GHI/61*
11630021	AAT Bioquest	500 tests	EUR 2051
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

iFluor® 430 Anti-human CD163 Antibody *GHI/61*
11630030	AAT Bioquest	100 tests	EUR 547
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

iFluor® 430 Anti-human CD163 Antibody *GHI/61*
11630031	AAT Bioquest	500 tests	EUR 2051
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

iFluor® 450 Anti-human CD163 Antibody *GHI/61*
11630040	AAT Bioquest	100 tests	EUR 547
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

iFluor® 450 Anti-human CD163 Antibody *GHI/61*
11630041	AAT Bioquest	500 tests	EUR 2051
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

iFluor® 488 Anti-human CD163 Antibody *GHI/61*
11630050	AAT Bioquest	100 tests	EUR 547
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

iFluor® 488 Anti-human CD163 Antibody *GHI/61*
11630051	AAT Bioquest	500 tests	EUR 2051
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

iFluor® 514 Anti-human CD163 Antibody *GHI/61*
11630060	AAT Bioquest	100 tests	EUR 547
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

iFluor® 514 Anti-human CD163 Antibody *GHI/61*
11630061	AAT Bioquest	500 tests	EUR 2051
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

iFluor® 532 Anti-human CD163 Antibody *GHI/61*
11630070	AAT Bioquest	100 tests	EUR 547
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

iFluor® 532 Anti-human CD163 Antibody *GHI/61*
11630071	AAT Bioquest	500 tests	EUR 2051
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

Effect of Serotype and Strain Diversity on Dengue Virus Replication in Australian Mosquito Vectors

Dengue virus (DENV) is the most important mosquito-borne viral pathogen of humans, comprising four serotypes (DENV-1 to -4) with a myriad of genotypes and strains. The kinetics of DENV replication within the mosquito following ingestion of a blood meal influence the pathogen’s ability to reach the salivary glands and thus the transmission potential. The influence of DENV serotype and strain diversity on virus kinetics in the two main vector species, Aedes aegypti and Ae. albopictus, has been poorly characterized. We tested whether DENV replication kinetics vary systematically among serotypes and strains, using Australian strains of the two vectors.

Mosquitoes were blood fed with two strains per serotype, and sampled at 3, 6, 10 and 14-days post-exposure. Virus infection in mosquito bodies, and dissemination of virus to legs and wings, was detected using qRT-PCR. For both vectors, we found significant differences among serotypes in proportions of mosquitoes infected, with higher numbers for DENV-1 and -2 versus other serotypes.

Consistent with this, we observed that DENV-1 and -2 generally replicated to higher RNA levels than other serotypes, particularly at earlier time points. There were no significant differences in either speed of infection or dissemination between the mosquito species. Our results suggest that DENV diversity may have important epidemiological consequences by influencing virus kinetics in mosquito vectors.

A Plant Virus Ensures Viral Stability in the Hemolymph of Vector Insects through Suppressing Prophenoloxidase Activation

 

Most plant viruses require vector insects for transmission. Viral stability in the hemolymph of vector insects is a prerequisite for successful transmission of persistent plant viruses. However, knowledge of whether the proteolytic activation of prophenoloxidase (PPO) affects the stability of persistent plant viruses remains elusive.

Here, we explored the interplay between rice stripe virus (RSV) and the PPO cascade of the vector small brown planthopper. Phenoloxidase (PO) activity was suppressed by RSV by approximately 60%.

When the PPO cascade was activated, we found distinct melanization around RSV particles and serious damage to viral stability in the hemolymph. Viral suppression of PO activity was derived from obstruction of proteolytic cleavage of PPOs by binding of the viral nonstructural protein NS3. These results indicate that RSV attenuates the PPO response to ensure viral stability in the hemolymph of vector insects. Our research provides enlightening cues for controlling the transmission of vector-borne viruses.

IMPORTANCE Large ratios of vector-borne plant viruses circulate in the hemolymph of their vector insects before entering the salivary glands to be transmitted to plants. The stability of virions in the hemolymph is vital in this process. Activation of the proteolytic prophenoloxidase (PPO) to produce active phenoloxidase (PO) is one of the major innate immune pathways in insect hemolymph.

How a plant virus copes with the PPO immune reaction in its vector insect remains unclear. Here, we report that the PPO affects the stability of rice stripe virus (RSV), a notorious rice virus, in the hemolymph of a vector insect, the small brown planthopper. RSV suppresses PPO activation using viral nonstructural protein. Once the level of PO activity is elevated, RSV is melanized and eliminated from the hemolymph. Our work gives valuable clues for developing novel strategies for controlling the transmission of vector-borne plant viruses.