Development of Tomato bushy stunt virus-based vectors for fusion and non-fusion
Clem
May 20, 2021
Development of Tomato bushy stunt virus-based vectors for fusion and non-fusion expression of heterologous proteins in an alternative host Nicotiana excelsiana
Plant virus-based expression systems are an alternative expression platform for the production of clinically and industrially useful recombinant proteins. Nonetheless, due to a lack of viral vector with the commercial potentials, it is urgent to design and develop new, versatile, and efficient plant virus vectors.
The genome of Tomato bushy stunt virus (TBSV) offers an attractive alternative to being modified as a vector for producing heterologous proteins in plants.
Here, we developed a set of novel fusion and non-fusion TBSV-CP replacement vectors, which provide more flexible and efficient tools for expressing proteins of interest in plants. An alternative tobacco plant, Nicotiana excelsiana, was used in this study as a host for newly constructed TBSV vectors because the unwanted necrotic effects were reported on the commonly used Nicotiana benthamiana host associated with expression of TBSV-encoded P19 protein.
The data showed that TBSV vectors caused a symptomless infection and overexpressed reporter gene in N. excelsiana leaves, demonstrating that N. excelsiana is an ideal host plant for TBSV-mediated heterologous gene expression. Moreover, a TBSV non-fusion vector, dAUG, shows the similar accumulation level of reporter proteins to that of TMV- and PVX-based vectors in side-by-side comparison and provides more flexible aspects than the previously developed TBSV vectors. Collectively, our newly developed TBSV expression system adds a new member to the family of plant viral expression vectors and meanwhile offers a flexible and highly effective approach for producing proteins of interest in plants.
KEY POINTS:
• The TBSV-based transient expression system has been significantly improved.
- The necrotic effects caused by viral P19 protein were avoided by the usage of N. excelsiana as a host plant.
- The expression level of the non-fusion vector was similar to the most effective virus vectors reported so far.

grdr
APC anti-human CD163 |
E16FHA163-025 |
EnoGene |
25 tests |
EUR 520 |
Description: Available in various conjugation types. |
APC anti-human CD163 |
E16FHA163-100 |
EnoGene |
100 tests |
EUR 1191.67 |
Description: Available in various conjugation types. |
FITC anti-human CD163 |
E16FHF163-025 |
EnoGene |
25 tests |
EUR 520 |
Description: Available in various conjugation types. |
FITC anti-human CD163 |
E16FHF163-100 |
EnoGene |
100 tests |
EUR 1191.67 |
Description: Available in various conjugation types. |
Biotin anti-human CD163 |
E16FHB163-025U |
EnoGene |
25 μg |
EUR 346.67 |
Description: Available in various conjugation types. |
Biotin anti-human CD163 |
E16FHB163-100U |
EnoGene |
100 μg |
EUR 780 |
Description: Available in various conjugation types. |
Purified anti-human CD163 |
E16FHU163-100U |
EnoGene |
100 μg |
EUR 433.33 |
Description: Available in various conjugation types. |
Recombinant Human CD163/CD163 Protein, His Tag |
E40KMH346 |
EnoGene |
20ug |
EUR 495 |
Human CD163 Protein |
E40KMPH6242 |
EnoGene |
20ug |
EUR 495 |
PE-Cy7 anti-human CD163 |
E16FHN163-025 |
EnoGene |
25 tests |
EUR 650 |
Description: Available in various conjugation types. |
PE-Cy7 anti-human CD163 |
E16FHN163-100 |
EnoGene |
100 tests |
EUR 1408.33 |
Description: Available in various conjugation types. |
Rabbit Anti Human CD163 Monoclonal Clone ABCC-3 |
IRBAHUCD163ABCC3C100UL |
Innovative research |
each |
EUR 496 |
|
Description: Rabbit Anti Human CD163 Monoclonal Clone ABCC-3 |
APC-Cy7 anti-human CD163 |
E16FHO163-025 |
EnoGene |
25 tests |
EUR 650 |
Description: Available in various conjugation types. |
APC-Cy7 anti-human CD163 |
E16FHO163-100 |
EnoGene |
100 tests |
EUR 1408.33 |
Description: Available in various conjugation types. |
PerCP-Cy5.5 anti-human CD163 |
E16FHS163-025 |
EnoGene |
25 tests |
EUR 541.67 |
Description: Available in various conjugation types. |
PerCP-Cy5.5 anti-human CD163 |
E16FHS163-100 |
EnoGene |
100 tests |
EUR 1278.33 |
Description: Available in various conjugation types. |
anti- CD163/M130 Antibody |
FNab09771 |
FN Test |
100µg |
EUR 658.5 |
|
Description: Antibody raised against CD163/M130 |
Anti-Hu CD163 PE |
1P-645-T025 |
ExBio |
25 tests |
EUR 168 |
Anti-Hu CD163 PE |
1P-645-T100 |
ExBio |
100 tests |
EUR 288 |
Anti-Hu CD163 APC |
1A-645-T025 |
ExBio |
25 tests |
EUR 168 |
Anti-Hu CD163 APC |
1A-645-T100 |
ExBio |
100 tests |
EUR 288 |
Anti-Hu CD163 Purified |
11-645-C025 |
ExBio |
0.025 mg |
EUR 118.8 |
Anti-Hu CD163 Purified |
11-645-C100 |
ExBio |
0.1 mg |
EUR 189.6 |
Human CD163, Fc Tag |
E24PHA282 |
EnoGene |
50 μg |
EUR 250 |
Human CD163, His Tag |
E24PHA281 |
EnoGene |
50 μg |
EUR 250 |
Human CD163 ELISA Kit |
LF-EK50890 |
Abfrontier |
1×96T |
EUR 777.6 |
Human CD163 shRNA Plasmid |
20-abx956176 |
Abbexa |
|
|
|
Recombinant Human CD163 Protein |
RP02295 |
Abclonal |
500μg |
EUR 1625 |
|
Human CellExp? CD163, Human recombinant |
9226-10 |
Biovision |
each |
EUR 366 |
Human CellExp? CD163, Human recombinant |
9226-50 |
Biovision |
each |
EUR 927.6 |
Anti-Hu CD163 PE-Cy7 |
T7-645-T025 |
ExBio |
25 tests |
EUR 184.8 |
Anti-Hu CD163 PE-Cy7 |
T7-645-T100 |
ExBio |
100 tests |
EUR 321.6 |
Anti-Hu CD163 PerCP-Cy5.5 |
T9-645-T025 |
ExBio |
25 tests |
EUR 235.2 |
Anti-Hu CD163 PerCP-Cy5.5 |
T9-645-T100 |
ExBio |
100 tests |
EUR 422.4 |
PE Anti-human CD163 Antibody *GHI/61* |
116301K0 |
AAT Bioquest |
25 tests |
EUR 383 |
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn |
PE Anti-human CD163 Antibody *GHI/61* |
116301K1 |
AAT Bioquest |
100 tests |
EUR 995 |
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn |
PE Anti-human CD163 Antibody *GHI/61* |
116301K2 |
AAT Bioquest |
500 tests |
EUR 2984 |
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn |
PE Anti-human CD163 Antibody *GHI/61* |
116301K0-25tests |
AAT Bioquest |
25 tests |
EUR 383 |
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen. |
PE Anti-human CD163 Antibody *GHI/61* |
116301K1-100tests |
AAT Bioquest |
100 tests |
EUR 995 |
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen. |
PE Anti-human CD163 Antibody *GHI/61* |
116301K2-500tests |
AAT Bioquest |
500 tests |
EUR 2984 |
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen. |
APC Anti-human CD163 Antibody *GHI/61* |
116301B0 |
AAT Bioquest |
25 tests |
EUR 383 |
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn |
APC Anti-human CD163 Antibody *GHI/61* |
116301B1 |
AAT Bioquest |
100 tests |
EUR 995 |
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn |
APC Anti-human CD163 Antibody *GHI/61* |
116301B2 |
AAT Bioquest |
500 tests |
EUR 2984 |
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn |
APC Anti-human CD163 Antibody *GHI/61* |
116301B0-25tests |
AAT Bioquest |
25 tests |
EUR 383 |
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen. |
APC Anti-human CD163 Antibody *GHI/61* |
116301B1-100tests |
AAT Bioquest |
100 tests |
EUR 995 |
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen. |
APC Anti-human CD163 Antibody *GHI/61* |
116301B2-500tests |
AAT Bioquest |
500 tests |
EUR 2984 |
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen. |
Alexa Fluor® 647 anti-human CD163 |
E16FHK163-025 |
EnoGene |
25 tests |
EUR 433.33 |
Description: Available in various conjugation types. |
Alexa Fluor® 647 anti-human CD163 |
E16FHK163-100 |
EnoGene |
100 tests |
EUR 975 |
Description: Available in various conjugation types. |
ELISA kit for Human CD163 |
EK5296 |
SAB |
96 tests |
EUR 663.6 |
Description: Enzyme-linked immunosorbent assay kit for quantification of Human CD163 in samples from serum, plasma, tissue homogenates and other biological fluids. |
FITC Anti-human CD163 Antibody *GHI/61* |
116301G0 |
AAT Bioquest |
100 tests |
EUR 547 |
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn |
FITC Anti-human CD163 Antibody *GHI/61* |
116301G1 |
AAT Bioquest |
500 tests |
EUR 2051 |
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn |
FITC Anti-human CD163 Antibody *GHI/61* |
116301G0-100tests |
AAT Bioquest |
100 tests |
EUR 547 |
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen. |
FITC Anti-human CD163 Antibody *GHI/61* |
116301G1-500tests |
AAT Bioquest |
500 tests |
EUR 2051 |
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen. |
TRITC Anti-human CD163 Antibody *GHI/61* |
116301H0 |
AAT Bioquest |
100 tests |
EUR 547 |
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn |
TRITC Anti-human CD163 Antibody *GHI/61* |
116301H1 |
AAT Bioquest |
500 tests |
EUR 2051 |
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn |
PerCP Anti-human CD163 Antibody *GHI/61* |
116301S0 |
AAT Bioquest |
25 tests |
EUR 383 |
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn |
PerCP Anti-human CD163 Antibody *GHI/61* |
116301S1 |
AAT Bioquest |
100 tests |
EUR 995 |
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn |
PerCP Anti-human CD163 Antibody *GHI/61* |
116301S2 |
AAT Bioquest |
500 tests |
EUR 2984 |
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn |
TRITC Anti-human CD163 Antibody *GHI/61* |
116301H0-100tests |
AAT Bioquest |
100 tests |
EUR 547 |
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen. |
TRITC Anti-human CD163 Antibody *GHI/61* |
116301H1-500tests |
AAT Bioquest |
500 tests |
EUR 2051 |
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen. |
PerCP Anti-human CD163 Antibody *GHI/61* |
116301S0-25tests |
AAT Bioquest |
25 tests |
EUR 383 |
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen. |
PerCP Anti-human CD163 Antibody *GHI/61* |
116301S1-100tests |
AAT Bioquest |
100 tests |
EUR 995 |
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen. |
PerCP Anti-human CD163 Antibody *GHI/61* |
116301S2-500tests |
AAT Bioquest |
500 tests |
EUR 2984 |
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen. |
Human CD163 Protein, His Tag |
CD3-H52E8 |
ACROBIOSYSTEMS |
1mg |
EUR 374.5 |
|
Description: Human CD163, His Tag (CD3-H52E8) is expressed from human 293 cells (HEK293). It contains AA Ser 42 - Ser 1045 (Accession # Q86VB7). |
Canine CD163 antigen(CD163 LISA kit |
GA-E0062CN-48T |
GenAsia Biotech |
48T |
EUR 482.4 |
Canine CD163 antigen(CD163 LISA kit |
GA-E0062CN-96T |
GenAsia Biotech |
96T |
EUR 820.8 |
PacBlue Anti-human CD163 Antibody *GHI/61* |
116301I0 |
AAT Bioquest |
100 tests |
EUR 547 |
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn |
PacBlue Anti-human CD163 Antibody *GHI/61* |
116301I1 |
AAT Bioquest |
500 tests |
EUR 2051 |
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn |
PacBlue Anti-human CD163 Antibody *GHI/61* |
116301I0-100tests |
AAT Bioquest |
100 tests |
EUR 547 |
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen. |
PacBlue Anti-human CD163 Antibody *GHI/61* |
116301I1-500tests |
AAT Bioquest |
500 tests |
EUR 2051 |
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen. |
Porcine CD163 antigen,CD163 LISA kit |
GA-E0045PC-48T |
GenAsia Biotech |
48T |
EUR 436.8 |
Porcine CD163 antigen,CD163 LISA kit |
GA-E0045PC-96T |
GenAsia Biotech |
96T |
EUR 708 |
Purified Anti-human CD163 Antibody *GHI/61* |
11630000 |
AAT Bioquest |
100 ug |
EUR 365 |
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn |
Purified Anti-human CD163 Antibody *GHI/61* |
11630000-100ug |
AAT Bioquest |
100 ug |
EUR 365 |
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen. |
PacOrange Anti-human CD163 Antibody *GHI/61* |
116301J0 |
AAT Bioquest |
100 tests |
EUR 547 |
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn |
PacOrange Anti-human CD163 Antibody *GHI/61* |
116301J1 |
AAT Bioquest |
500 tests |
EUR 2051 |
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn |
PacOrange Anti-human CD163 Antibody *GHI/61* |
116301J0-100tests |
AAT Bioquest |
100 tests |
EUR 547 |
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen. |
PacOrange Anti-human CD163 Antibody *GHI/61* |
116301J1-500tests |
AAT Bioquest |
500 tests |
EUR 2051 |
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen. |
Human CD163 PicoKine ELISA Kit |
EK0715 |
BosterBio |
96 wells |
EUR 510 |
Description: For quantitative detection of human CD163 in cell culture supernates, serum and plasma(heparin). |
Human CD163 Protein Lysate 20ug |
IHUCD163PLLY20UG |
Innovative research |
each |
EUR 213 |
|
Description: Human CD163 Protein Lysate 20ug |
CD163 Antibody |
20-abx242956 |
Abbexa |
|
|
|
CD163 antibody |
10R-6496 |
Fitzgerald |
100 ug |
EUR 243.6 |
Description: Mouse monoclonal CD163 antibody |
CD163 antibody |
10R-CD163aRT |
Fitzgerald |
250 ug |
EUR 859.2 |
Description: Mouse monoclonal CD163 antibody |
CD163 Antibody |
37157-100ul |
SAB |
100ul |
EUR 302.4 |
CD163 Antibody |
49553-100ul |
SAB |
100ul |
EUR 399.6 |
CD163 Antibody |
49553-50ul |
SAB |
50ul |
EUR 286.8 |
CD163 Antibody |
1-CSB-PA969205 |
Cusabio |
|
|
|
Description: A polyclonal antibody against CD163. Recognizes CD163 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:1000-1:2000, IHC:1:25-1:100 |
CD163 Antibody |
1-CSB-PA801238LA01HU |
Cusabio |
|
|
|
Description: A polyclonal antibody against CD163. Recognizes CD163 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IF; Recommended dilution: IF:1:50-1:200 |
Cd163 Antibody |
1-CSB-PA650452LA01MO |
Cusabio |
|
|
|
Description: A polyclonal antibody against Cd163. Recognizes Cd163 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB; Recommended dilution: WB:1:500-1:2000 |
CD163 Antibody |
F50316-0.4ML |
NSJ Bioreagents |
0.4 ml |
EUR 322.15 |
Description: CD163 is an acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. The protein may play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. It binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. And it exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. It also induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. |
CD163 Antibody |
F50316-0.08ML |
NSJ Bioreagents |
0.08 ml |
EUR 140.25 |
Description: CD163 is an acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. The protein may play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. It binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. And it exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. It also induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. |
CD163 Antibody |
RQ4259 |
NSJ Bioreagents |
100 ug |
EUR 356.15 |
Description: CD163 (Cluster of Differentiation 163) is a protein that in humans is encoded by the CD163 gene. The protein encoded by this gene is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. It functions as an acute phase-regulated receptor involved in the clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages, and may thereby protect tissues from free hemoglobin-mediated oxidative damage. This protein may also function as an innate immune sensor for bacteria and inducer of local inflammation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. |
CD163 Antibody |
V7470-100UG |
NSJ Bioreagents |
100 ug |
EUR 349.3 |
Description: This antibody recognizes a protein of 140kDa, identified as CD163. It has been identified as an acute phase-regulated transmembrane protein whose function is to mediate the endocytosis of haptoglobin-hemoglobin complexes. This receptor is expressed on the surface of monocytes with low expression and on tissue macrophages, histiocytes with high expression. Staining with anti-CD163 has been helpful to distinguish synovial macrophages from synovial intimal fibroblasts in rheumatoid arthritis, where its specificity for macrophages was found to be superior to that of anti-CD68. Increased levels of CD163 were also detected in patients with microbial infections and myelomonocytic leukemias. Anti-CD163 is of considerable value for selective identification of monocytes and macrophages at a certain stage of differentiation and is suitable for diagnosing myelomonocytic or monocytic leukaemia and neoplasms of true histiocytic origin. CD163 is positive in skin (histiocytes), gut, Kupffer cells, a few alveolar macrophages, macrophages in the placenta, and in macrophages in inflamed tissues including tumor tissue. |
CD163 Antibody |
V7470-20UG |
NSJ Bioreagents |
20 ug |
EUR 153.3 |
Description: This antibody recognizes a protein of 140kDa, identified as CD163. It has been identified as an acute phase-regulated transmembrane protein whose function is to mediate the endocytosis of haptoglobin-hemoglobin complexes. This receptor is expressed on the surface of monocytes with low expression and on tissue macrophages, histiocytes with high expression. Staining with anti-CD163 has been helpful to distinguish synovial macrophages from synovial intimal fibroblasts in rheumatoid arthritis, where its specificity for macrophages was found to be superior to that of anti-CD68. Increased levels of CD163 were also detected in patients with microbial infections and myelomonocytic leukemias. Anti-CD163 is of considerable value for selective identification of monocytes and macrophages at a certain stage of differentiation and is suitable for diagnosing myelomonocytic or monocytic leukaemia and neoplasms of true histiocytic origin. CD163 is positive in skin (histiocytes), gut, Kupffer cells, a few alveolar macrophages, macrophages in the placenta, and in macrophages in inflamed tissues including tumor tissue. |
CD163 Antibody |
V7470IHC-7ML |
NSJ Bioreagents |
7 ml |
EUR 349.3 |
Description: This antibody recognizes a protein of 140kDa, identified as CD163. It has been identified as an acute phase-regulated transmembrane protein whose function is to mediate the endocytosis of haptoglobin-hemoglobin complexes. This receptor is expressed on the surface of monocytes with low expression and on tissue macrophages, histiocytes with high expression. Staining with anti-CD163 has been helpful to distinguish synovial macrophages from synovial intimal fibroblasts in rheumatoid arthritis, where its specificity for macrophages was found to be superior to that of anti-CD68. Increased levels of CD163 were also detected in patients with microbial infections and myelomonocytic leukemias. Anti-CD163 is of considerable value for selective identification of monocytes and macrophages at a certain stage of differentiation and is suitable for diagnosing myelomonocytic or monocytic leukaemia and neoplasms of true histiocytic origin. CD163 is positive in skin (histiocytes), gut, Kupffer cells, a few alveolar macrophages, macrophages in the placenta, and in macrophages in inflamed tissues including tumor tissue. |
CD163 Antibody |
V7470SAF-100UG |
NSJ Bioreagents |
100 ug |
EUR 349.3 |
Description: This antibody recognizes a protein of 140kDa, identified as CD163. It has been identified as an acute phase-regulated transmembrane protein whose function is to mediate the endocytosis of haptoglobin-hemoglobin complexes. This receptor is expressed on the surface of monocytes with low expression and on tissue macrophages, histiocytes with high expression. Staining with anti-CD163 has been helpful to distinguish synovial macrophages from synovial intimal fibroblasts in rheumatoid arthritis, where its specificity for macrophages was found to be superior to that of anti-CD68. Increased levels of CD163 were also detected in patients with microbial infections and myelomonocytic leukemias. Anti-CD163 is of considerable value for selective identification of monocytes and macrophages at a certain stage of differentiation and is suitable for diagnosing myelomonocytic or monocytic leukaemia and neoplasms of true histiocytic origin. CD163 is positive in skin (histiocytes), gut, Kupffer cells, a few alveolar macrophages, macrophages in the placenta, and in macrophages in inflamed tissues including tumor tissue. |
CD163 Antibody |
V8227-100UG |
NSJ Bioreagents |
100 ug |
EUR 349.3 |
Description: This MAb recognizes a protein of 140kDa, identified as CD163. It has been identified as an acute phase-regulated transmembrane protein whose function is to mediate the endocytosis of haptoglobin-hemoglobin complexes. This receptor is expressed on the surface of monocytes with low expression and on tissue macrophages, histiocytes with high expression. Staining with anti-CD163 has been helpful to distinguish synovial macrophages from synovial intimal fibroblasts in rheumatoid arthritis, where its specificity for macrophages was found to be superior to that of anti-CD68. Increased levels of CD163 were also detected in patients with microbial infections and myelomonocytic leukemias. Anti-CD163 is of considerable value for selective identification of monocytes and macrophages at a certain stage of differentiation and is suitable for diagnosing myelomonocytic or monocytic leukaemia and neoplasms of true histiocytic origin. CD163 is positive in skin (histiocytes), gut, Kupffer cells, a few alveolar macrophages, macrophages in the placenta, and in macrophages in inflamed tissues including tumor tissue. |
CD163 Antibody |
V8227-20UG |
NSJ Bioreagents |
20 ug |
EUR 153.3 |
Description: This MAb recognizes a protein of 140kDa, identified as CD163. It has been identified as an acute phase-regulated transmembrane protein whose function is to mediate the endocytosis of haptoglobin-hemoglobin complexes. This receptor is expressed on the surface of monocytes with low expression and on tissue macrophages, histiocytes with high expression. Staining with anti-CD163 has been helpful to distinguish synovial macrophages from synovial intimal fibroblasts in rheumatoid arthritis, where its specificity for macrophages was found to be superior to that of anti-CD68. Increased levels of CD163 were also detected in patients with microbial infections and myelomonocytic leukemias. Anti-CD163 is of considerable value for selective identification of monocytes and macrophages at a certain stage of differentiation and is suitable for diagnosing myelomonocytic or monocytic leukaemia and neoplasms of true histiocytic origin. CD163 is positive in skin (histiocytes), gut, Kupffer cells, a few alveolar macrophages, macrophages in the placenta, and in macrophages in inflamed tissues including tumor tissue. |
CD163 Antibody |
V8227SAF-100UG |
NSJ Bioreagents |
100 ug |
EUR 349.3 |
Description: This MAb recognizes a protein of 140kDa, identified as CD163. It has been identified as an acute phase-regulated transmembrane protein whose function is to mediate the endocytosis of haptoglobin-hemoglobin complexes. This receptor is expressed on the surface of monocytes with low expression and on tissue macrophages, histiocytes with high expression. Staining with anti-CD163 has been helpful to distinguish synovial macrophages from synovial intimal fibroblasts in rheumatoid arthritis, where its specificity for macrophages was found to be superior to that of anti-CD68. Increased levels of CD163 were also detected in patients with microbial infections and myelomonocytic leukemias. Anti-CD163 is of considerable value for selective identification of monocytes and macrophages at a certain stage of differentiation and is suitable for diagnosing myelomonocytic or monocytic leukaemia and neoplasms of true histiocytic origin. CD163 is positive in skin (histiocytes), gut, Kupffer cells, a few alveolar macrophages, macrophages in the placenta, and in macrophages in inflamed tissues including tumor tissue. |
CD163 Antibody |
V8415-100UG |
NSJ Bioreagents |
100 ug |
EUR 349.3 |
Description: This MAb recognizes a protein of 140kDa, identified as CD163. It has been identified as an acute phase-regulated transmembrane protein whose function is to mediate the endocytosis of haptoglobin-hemoglobin complexes. This receptor is expressed on the surface of monocytes with low expression and on tissue macrophages, histiocytes with high expression. Staining with anti-CD163 has been helpful to distinguish synovial macrophages from synovial intimal fibroblasts in rheumatoid arthritis, where its specificity for macrophages was found to be superior to that of anti-CD68. Increased levels of CD163 were also detected in patients with microbial infections and myelomonocytic leukemias. Anti-CD163 is of considerable value for selective identification of monocytes and macrophages at a certain stage of differentiation and is suitable for diagnosing myelomonocytic or monocytic leukaemia and neoplasms of true histiocytic origin. CD163 is positive in skin (histiocytes), gut, Kupffer cells, a few alveolar macrophages, macrophages in the placenta, and in macrophages in inflamed tissues including tumor tissue. |
CD163 Antibody |
V8415-20UG |
NSJ Bioreagents |
20 ug |
EUR 153.3 |
Description: This MAb recognizes a protein of 140kDa, identified as CD163. It has been identified as an acute phase-regulated transmembrane protein whose function is to mediate the endocytosis of haptoglobin-hemoglobin complexes. This receptor is expressed on the surface of monocytes with low expression and on tissue macrophages, histiocytes with high expression. Staining with anti-CD163 has been helpful to distinguish synovial macrophages from synovial intimal fibroblasts in rheumatoid arthritis, where its specificity for macrophages was found to be superior to that of anti-CD68. Increased levels of CD163 were also detected in patients with microbial infections and myelomonocytic leukemias. Anti-CD163 is of considerable value for selective identification of monocytes and macrophages at a certain stage of differentiation and is suitable for diagnosing myelomonocytic or monocytic leukaemia and neoplasms of true histiocytic origin. CD163 is positive in skin (histiocytes), gut, Kupffer cells, a few alveolar macrophages, macrophages in the placenta, and in macrophages in inflamed tissues including tumor tissue. |
CD163 Antibody |
V8415SAF-100UG |
NSJ Bioreagents |
100 ug |
EUR 349.3 |
Description: This MAb recognizes a protein of 140kDa, identified as CD163. It has been identified as an acute phase-regulated transmembrane protein whose function is to mediate the endocytosis of haptoglobin-hemoglobin complexes. This receptor is expressed on the surface of monocytes with low expression and on tissue macrophages, histiocytes with high expression. Staining with anti-CD163 has been helpful to distinguish synovial macrophages from synovial intimal fibroblasts in rheumatoid arthritis, where its specificity for macrophages was found to be superior to that of anti-CD68. Increased levels of CD163 were also detected in patients with microbial infections and myelomonocytic leukemias. Anti-CD163 is of considerable value for selective identification of monocytes and macrophages at a certain stage of differentiation and is suitable for diagnosing myelomonocytic or monocytic leukaemia and neoplasms of true histiocytic origin. CD163 is positive in skin (histiocytes), gut, Kupffer cells, a few alveolar macrophages, macrophages in the placenta, and in macrophages in inflamed tissues including tumor tissue. |
CD163 Antibody |
V8757-100UG |
NSJ Bioreagents |
100 ug |
EUR 349.3 |
Description: CD163 is a type I membrane protein, and is a member of the hemoglobin scavenger receptor cystein-rich superfamily. The protein is involved in the clearance of hemoglobin-haptoglobin complexes and is considered to have anti-inflammatory functions. CD163 expression is restricted to the monocytic/macrophage lineage. It is expressed by all circulating monocytes and by a majority of tissue macrophages, such as splenic dendrocytes, alveolar macrophages and Kupffer cells of the liver. It is not present in macrophages in the mantle zone and some of the germinal center cells in lymph follicles, nor in Langerhans cells and interdigitating reticulum cells. In tumor tissues, CD163 is found in almost all cases of acute myeloid leukemia with monocytoid differentiation and in the majority of cases of histiocytic sarcoma, littoral cell angioma, Rosai-Dorfman disease, Langerhans cell histiocytosis and typical and atypical fibrous histiocytoma. It is also expressed in some cases of dermatofibrosarcoma protuberans. CD163 can be used to detect cells of monocytic and histiocyte lineage in neoplastic and reactive lesions. It has been shown to be more sensitive than CD68 for the detection of macrophages and monocytic cells. It covers a similar, but not identical, spectrum of cells as CD68. |
CD163 Antibody |
V8757-20UG |
NSJ Bioreagents |
20 ug |
EUR 153.3 |
Description: CD163 is a type I membrane protein, and is a member of the hemoglobin scavenger receptor cystein-rich superfamily. The protein is involved in the clearance of hemoglobin-haptoglobin complexes and is considered to have anti-inflammatory functions. CD163 expression is restricted to the monocytic/macrophage lineage. It is expressed by all circulating monocytes and by a majority of tissue macrophages, such as splenic dendrocytes, alveolar macrophages and Kupffer cells of the liver. It is not present in macrophages in the mantle zone and some of the germinal center cells in lymph follicles, nor in Langerhans cells and interdigitating reticulum cells. In tumor tissues, CD163 is found in almost all cases of acute myeloid leukemia with monocytoid differentiation and in the majority of cases of histiocytic sarcoma, littoral cell angioma, Rosai-Dorfman disease, Langerhans cell histiocytosis and typical and atypical fibrous histiocytoma. It is also expressed in some cases of dermatofibrosarcoma protuberans. CD163 can be used to detect cells of monocytic and histiocyte lineage in neoplastic and reactive lesions. It has been shown to be more sensitive than CD68 for the detection of macrophages and monocytic cells. It covers a similar, but not identical, spectrum of cells as CD68. |
CD163 Antibody |
V8757SAF-100UG |
NSJ Bioreagents |
100 ug |
EUR 349.3 |
Description: CD163 is a type I membrane protein, and is a member of the hemoglobin scavenger receptor cystein-rich superfamily. The protein is involved in the clearance of hemoglobin-haptoglobin complexes and is considered to have anti-inflammatory functions. CD163 expression is restricted to the monocytic/macrophage lineage. It is expressed by all circulating monocytes and by a majority of tissue macrophages, such as splenic dendrocytes, alveolar macrophages and Kupffer cells of the liver. It is not present in macrophages in the mantle zone and some of the germinal center cells in lymph follicles, nor in Langerhans cells and interdigitating reticulum cells. In tumor tissues, CD163 is found in almost all cases of acute myeloid leukemia with monocytoid differentiation and in the majority of cases of histiocytic sarcoma, littoral cell angioma, Rosai-Dorfman disease, Langerhans cell histiocytosis and typical and atypical fibrous histiocytoma. It is also expressed in some cases of dermatofibrosarcoma protuberans. CD163 can be used to detect cells of monocytic and histiocyte lineage in neoplastic and reactive lesions. It has been shown to be more sensitive than CD68 for the detection of macrophages and monocytic cells. It covers a similar, but not identical, spectrum of cells as CD68. |
CD163 Antibody |
R30973 |
NSJ Bioreagents |
100 ug |
EUR 356.15 |
Description: CD163 (Cluster of Differentiation 163) is a human protein encoded by the CD163 gene. The receptor belongs to the scavenger receptor cysteine rich family type B and consists of an 1048 amino acid residues extracellular domain, a single transmembrane segment and a cytoplasmic tail with several splice variants. CD163 is a scavenger receptor for the hemoglobin-haptoglobincomplex. Using FISH, somatic cell hybrid analysis, and radiation hybrid analysis, Stover et al.(2000) mapped the CD163 gene to chromosome 12p13.3. Specific CD163-mediated endocytosis of haptoglobin-hemoglobin complexes was measurable in cells transfected with CD163 cDNA and in CD163-expressing myelomonocytic lymphoma cells.CD163 expression in monocytes promoted bacteria-induced proinflammatory cytokine production that could be blocked by anti-CD163 antibodies. Cells expressing human CD163 and recombinant protein containing the extracellular domain of CD163 supported adhesion of erythroblastic cells. |
CD163 Antibody |
R30974 |
NSJ Bioreagents |
100 ug |
EUR 356.15 |
Description: Cluster of Differentiation 163, also known as Hemoglobin scavenger receptor, is a human protein encoded by the CD163 gene. The receptor belongs to the scavenger receptor cysteine rich family type B and consists of an 1048 amino acid residues extracellular domain, a single transmembrane segment and a cytoplasmic tail with several splice variants. CD163 is a scavenger receptorfor the hemoglobin-haptoglobin complex. Using FISH, somatic cell hybrid analysis, and radiation hybrid analysis, Stover et al.(2000) mapped the gene to chromosome 12p13.3. CD163 expression in monocytes promoted bacteria-induced proinflammatory cytokine production that could be blocked by CD163 antibody. Cells expressing human CD163 and recombinant protein containing the extracellular domain of CD163 supported adhesion of erythroblastic cells. |
CD163 Antibody |
V3937-100UG |
NSJ Bioreagents |
100 ug |
EUR 349.3 |
Description: This antibody recognizes a protein of 140kDa, identified as CD163. It has been identified as an acute phase-regulated transmembrane protein whose function is to mediate the endocytosis of haptoglobin-hemoglobin complexes. This receptor is expressed on the surface of monocytes with low expression and on tissue macrophages, histiocytes with high expression. Staining with anti-CD163 has been helpful to distinguish synovial macrophages from synovial intimal fibroblasts in rheumatoid arthritis, where its specificity for macrophages was found to be superior to that of anti-CD68. Increased levels of CD163 were also detected in patients with microbial infections and myelomonocytic leukemias. Anti-CD163 is of considerable value for selective identification of monocytes and macrophages at a certain stage of differentiation and is suitable for diagnosing myelomonocytic or monocytic leukaemia and neoplasms of true histiocytic origin. CD163 is positive in skin (histiocytes), gut, Kupffer cells, a few alveolar macrophages, macrophages in the placenta, and in macrophages in inflamed tissues including tumor tissue. |
CD163 Antibody |
V3937-20UG |
NSJ Bioreagents |
20 ug |
EUR 153.3 |
Description: This antibody recognizes a protein of 140kDa, identified as CD163. It has been identified as an acute phase-regulated transmembrane protein whose function is to mediate the endocytosis of haptoglobin-hemoglobin complexes. This receptor is expressed on the surface of monocytes with low expression and on tissue macrophages, histiocytes with high expression. Staining with anti-CD163 has been helpful to distinguish synovial macrophages from synovial intimal fibroblasts in rheumatoid arthritis, where its specificity for macrophages was found to be superior to that of anti-CD68. Increased levels of CD163 were also detected in patients with microbial infections and myelomonocytic leukemias. Anti-CD163 is of considerable value for selective identification of monocytes and macrophages at a certain stage of differentiation and is suitable for diagnosing myelomonocytic or monocytic leukaemia and neoplasms of true histiocytic origin. CD163 is positive in skin (histiocytes), gut, Kupffer cells, a few alveolar macrophages, macrophages in the placenta, and in macrophages in inflamed tissues including tumor tissue. |
CD163 Antibody |
V3937SAF-100UG |
NSJ Bioreagents |
100 ug |
EUR 349.3 |
Description: This antibody recognizes a protein of 140kDa, identified as CD163. It has been identified as an acute phase-regulated transmembrane protein whose function is to mediate the endocytosis of haptoglobin-hemoglobin complexes. This receptor is expressed on the surface of monocytes with low expression and on tissue macrophages, histiocytes with high expression. Staining with anti-CD163 has been helpful to distinguish synovial macrophages from synovial intimal fibroblasts in rheumatoid arthritis, where its specificity for macrophages was found to be superior to that of anti-CD68. Increased levels of CD163 were also detected in patients with microbial infections and myelomonocytic leukemias. Anti-CD163 is of considerable value for selective identification of monocytes and macrophages at a certain stage of differentiation and is suitable for diagnosing myelomonocytic or monocytic leukaemia and neoplasms of true histiocytic origin. CD163 is positive in skin (histiocytes), gut, Kupffer cells, a few alveolar macrophages, macrophages in the placenta, and in macrophages in inflamed tissues including tumor tissue. |
CD163 Antibody |
E037157 |
EnoGene |
100μg/100μl |
EUR 255 |
Description: Available in various conjugation types. |
CD163 Antibody |
E19-8235-1 |
EnoGene |
50ug/50ul |
EUR 145 |
Description: Available in various conjugation types. |
CD163 Antibody |
E19-8235-2 |
EnoGene |
100ug/100ul |
EUR 225 |
Description: Available in various conjugation types. |
CD163 Antibody |
E38PA9656 |
EnoGene |
100ul |
EUR 225 |
Description: Available in various conjugation types. |
CD163 Antibody |
E39-10799 |
EnoGene |
100ug/100ul |
EUR 225 |
Description: Available in various conjugation types. |
CD163 ORF Vector (Human) (pORF) |
ORF017045 |
ABM |
1.0 ug DNA |
EUR 486 |
CD163 ELISA Kit (Human) (OKBB00786) |
OKBB00786 |
Aviva Systems Biology |
96 Wells |
EUR 606 |
Description: Description of target: CD163(Cluster of Differentiation 163) is a human protein encoded by the CD163 gene. It has also been shown to mark cells of monocyte/macrophage lineage. CD163, a member of the scavenger receptor cysteine-rich(SRCR) superfamily, is exclusively expressed by monocytes and macrophages. Using FISH, somatic cell hybrid analysis, and radiation hybrid analysis, CD163 gene was mapped the to chromosome 12p13.3. CD163 is upregulated in a large range of diseases inflammatory diseases including type 2 diabetes, macrophage activation sickness, Tangier's disease, reumatoid arthritis etc.;Species reactivity: Human;Application: ELISA;Assay info: ;Sensitivity: <150pg/ml |
CD163 ELISA Kit (Human) (OKAN04666) |
OKAN04666 |
Aviva Systems Biology |
96 Wells |
EUR 950.4 |
Description: Description of target: The protein encoded by this gene is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. It functions as an acute phase-regulated receptor involved in the clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages, and may thereby protect tissues from free hemoglobin-mediated oxidative damage. This protein may also function as an innate immune sensor for bacteria and inducer of local inflammation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.273 ng/mL |
CD163 ELISA Kit (Human) (OKBB01513) |
OKBB01513 |
Aviva Systems Biology |
96 Wells |
EUR 684 |
Description: Description of target: CD163(Cluster of Differentiation 163) is a human protein encoded by the CD163 gene. It has also been shown to mark cells of monocyte/macrophage lineage. CD163, a member of the scavenger receptor cysteine-rich(SRCR) superfamily, is exclusively expressed by monocytes and macrophages. Using FISH, somatic cell hybrid analysis, and radiation hybrid analysis, CD163 gene was mapped the to chromosome 12p13.3. CD163 is upregulated in a large range of diseases inflammatory diseases including type 2 diabetes, macrophage activation sickness, Tangier's disease, reumatoid arthritis etc.;Species reactivity: Human;Application: ELISA;Assay info: ;Sensitivity: <150pg/ml |
CD163 ELISA Kit (Human) (OKCD07621) |
OKCD07621 |
Aviva Systems Biology |
96 Wells |
EUR 1123.2 |
Description: Description of target: The protein encoded by this gene is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. It functions as an acute phase-regulated receptor involved in the clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages, and may thereby protect tissues from free hemoglobin-mediated oxidative damage. This protein may also function as an innate immune sensor for bacteria and inducer of local inflammation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.;Species reactivity: Human;Application: ELISA;Assay info: ;Sensitivity: < 0.273ng/mL |
CD163 |
pro-2496 |
ProSpec Tany |
1µg |
EUR 60 |
Description: Recombinant Human CD163 |
CD163 |
E8ET1704-43 |
EnoGene |
100ul |
EUR 275 |
Description: Available in various conjugation types. |
CD163 |
E8ER1804-03 |
EnoGene |
100ul |
EUR 275 |
Description: Available in various conjugation types. |
QuickDetect? CD163 (Human) ELISA Kit |
K4422-100 |
Biovision |
each |
EUR 966 |
PE/Cy5 Anti-human CD163 Antibody *GHI/61* |
116301L0 |
AAT Bioquest |
25 tests |
EUR 429 |
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn |
PE/Cy5 Anti-human CD163 Antibody *GHI/61* |
116301L1 |
AAT Bioquest |
100 tests |
EUR 1117 |
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn |
PE/Cy5 Anti-human CD163 Antibody *GHI/61* |
116301L2 |
AAT Bioquest |
500 tests |
EUR 3351 |
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn |
PE/Cy7 Anti-human CD163 Antibody *GHI/61* |
116301M0 |
AAT Bioquest |
25 tests |
EUR 429 |
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn |
PE/Cy7 Anti-human CD163 Antibody *GHI/61* |
116301M1 |
AAT Bioquest |
100 tests |
EUR 1117 |
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn |
PE/Cy7 Anti-human CD163 Antibody *GHI/61* |
116301M2 |
AAT Bioquest |
500 tests |
EUR 3351 |
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn |
PE/Cy5 Anti-human CD163 Antibody *GHI/61* |
116301L0-25tests |
AAT Bioquest |
25 tests |
EUR 429 |
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen. |
PE/Cy5 Anti-human CD163 Antibody *GHI/61* |
116301L1-100tests |
AAT Bioquest |
100 tests |
EUR 1117 |
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen. |
PE/Cy5 Anti-human CD163 Antibody *GHI/61* |
116301L2-500tests |
AAT Bioquest |
500 tests |
EUR 3351 |
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen. |
PE/Cy7 Anti-human CD163 Antibody *GHI/61* |
116301M0-25tests |
AAT Bioquest |
25 tests |
EUR 429 |
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen. |
PE/Cy7 Anti-human CD163 Antibody *GHI/61* |
116301M1-100tests |
AAT Bioquest |
100 tests |
EUR 1117 |
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen. |
PE/Cy7 Anti-human CD163 Antibody *GHI/61* |
116301M2-500tests |
AAT Bioquest |
500 tests |
EUR 3351 |
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen. |
APC/Cy7 Anti-human CD163 Antibody *GHI/61* |
116301C0 |
AAT Bioquest |
25 tests |
EUR 429 |
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn |
APC/Cy7 Anti-human CD163 Antibody *GHI/61* |
116301C1 |
AAT Bioquest |
100 tests |
EUR 1117 |
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn |
APC/Cy7 Anti-human CD163 Antibody *GHI/61* |
116301C2 |
AAT Bioquest |
500 tests |
EUR 3351 |
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn |
APC/Cy7 Anti-human CD163 Antibody *GHI/61* |
116301C0-25tests |
AAT Bioquest |
25 tests |
EUR 429 |
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen. |
APC/Cy7 Anti-human CD163 Antibody *GHI/61* |
116301C1-100tests |
AAT Bioquest |
100 tests |
EUR 1117 |
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen. |
APC/Cy7 Anti-human CD163 Antibody *GHI/61* |
116301C2-500tests |
AAT Bioquest |
500 tests |
EUR 3351 |
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen. |
PerCP/Cy5.5 Anti-human CD163 Antibody *GHI/61* |
116301T0 |
AAT Bioquest |
25 tests |
EUR 429 |
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn |
PerCP/Cy5.5 Anti-human CD163 Antibody *GHI/61* |
116301T1 |
AAT Bioquest |
100 tests |
EUR 1117 |
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn |
PerCP/Cy5.5 Anti-human CD163 Antibody *GHI/61* |
116301T2 |
AAT Bioquest |
500 tests |
EUR 3351 |
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn |
PerCP/Cy5.5 Anti-human CD163 Antibody *GHI/61* |
116301T0-25tests |
AAT Bioquest |
25 tests |
EUR 429 |
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen. |
PerCP/Cy5.5 Anti-human CD163 Antibody *GHI/61* |
116301T1-100tests |
AAT Bioquest |
100 tests |
EUR 1117 |
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen. |
PerCP/Cy5.5 Anti-human CD163 Antibody *GHI/61* |
116301T2-500tests |
AAT Bioquest |
500 tests |
EUR 3351 |
Description: GHI/61 is an anti-human monoclonal antibody that forms an immune complex with the CD163 antigen. |
Anti-Human CD163 DyLight® 488 conjugated Antibody |
A00812-Dyl488 |
BosterBio |
100ug/vial |
EUR 412.8 |
Anti-Human CD163 DyLight® 550 conjugated Antibody |
A00812-Dyl550 |
BosterBio |
100ug/vial |
EUR 412.8 |
Mouse Anti-Human CD163 monoclonal antibody, clone JID274 |
CABT-L2938-100uL500uL |
Creative Diagnostics |
100 uL, 500 uL |
EUR 602.4 |
CD163 (ABT-CD163) Mouse mAb |
E2252704 |
EnoGene |
100ul |
EUR 225 |
Description: Available in various conjugation types. |
Human soluble CD163(sCD163) ELISA Kit |
1-CSB-E14050h |
Cusabio |
-
EUR 952.80
-
EUR 6033.60
-
EUR 3200.40
|
- 1 plate of 96 wells
- 10 plates of 96 wells each
- 5 plates of 96 wells each
|
|
Description: Quantitativesandwich ELISA kit for measuring Human soluble CD163(sCD163) in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
Human soluble CD163(sCD163) ELISA Kit |
CSB-E14050h-24T |
Cusabio |
1 plate of 24 wells |
EUR 198 |
|
Description: Quantitativesandwich ELISA kit for measuring Human soluble CD163 (sCD163) in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
Human Soluble CD163 (sCD163) ELISA Kit |
KTE62428-96T5 |
Abbkine |
96 T×5 |
EUR 2629 |
Description: This Human Soluble CD163 (sCD163) ELISA Kit employs a two-site sandwich ELISA to quantitate CD163. |
Human Soluble CD163 (sCD163) ELISA Kit |
KTE62428-96T50 |
Abbkine |
96 T×50 |
EUR 24569 |
Description: This Human Soluble CD163 (sCD163) ELISA Kit employs a two-site sandwich ELISA to quantitate CD163. |
Human soluble CD163(sCD163) ELISA Kit |
SL2931Hu |
Sunlong |
96 Tests |
EUR 468 |
|
CD163 antibody (PE) |
61R-1319 |
Fitzgerald |
100 tests |
EUR 483.6 |
Description: Mouse monoclonal CD163 antibody (PE) |
iFluor® 350 Anti-human CD163 Antibody *GHI/61* |
11630010 |
AAT Bioquest |
100 tests |
EUR 547 |
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn |
iFluor® 350 Anti-human CD163 Antibody *GHI/61* |
11630011 |
AAT Bioquest |
500 tests |
EUR 2051 |
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn |
iFluor® 405 Anti-human CD163 Antibody *GHI/61* |
11630020 |
AAT Bioquest |
100 tests |
EUR 547 |
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn |
iFluor® 405 Anti-human CD163 Antibody *GHI/61* |
11630021 |
AAT Bioquest |
500 tests |
EUR 2051 |
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn |
iFluor® 430 Anti-human CD163 Antibody *GHI/61* |
11630030 |
AAT Bioquest |
100 tests |
EUR 547 |
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn |
iFluor® 430 Anti-human CD163 Antibody *GHI/61* |
11630031 |
AAT Bioquest |
500 tests |
EUR 2051 |
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn |
iFluor® 450 Anti-human CD163 Antibody *GHI/61* |
11630040 |
AAT Bioquest |
100 tests |
EUR 547 |
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn |
iFluor® 450 Anti-human CD163 Antibody *GHI/61* |
11630041 |
AAT Bioquest |
500 tests |
EUR 2051 |
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn |
iFluor® 488 Anti-human CD163 Antibody *GHI/61* |
11630050 |
AAT Bioquest |
100 tests |
EUR 547 |
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn |
iFluor® 488 Anti-human CD163 Antibody *GHI/61* |
11630051 |
AAT Bioquest |
500 tests |
EUR 2051 |
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn |
iFluor® 514 Anti-human CD163 Antibody *GHI/61* |
11630060 |
AAT Bioquest |
100 tests |
EUR 547 |
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn |
iFluor® 514 Anti-human CD163 Antibody *GHI/61* |
11630061 |
AAT Bioquest |
500 tests |
EUR 2051 |
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn |
iFluor® 532 Anti-human CD163 Antibody *GHI/61* |
11630070 |
AAT Bioquest |
100 tests |
EUR 547 |
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn |
iFluor® 532 Anti-human CD163 Antibody *GHI/61* |
11630071 |
AAT Bioquest |
500 tests |
EUR 2051 |
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn |
Effect of Serotype and Strain Diversity on Dengue Virus Replication in Australian Mosquito Vectors
Dengue virus (DENV) is the most important mosquito-borne viral pathogen of humans, comprising four serotypes (DENV-1 to -4) with a myriad of genotypes and strains. The kinetics of DENV replication within the mosquito following ingestion of a blood meal influence the pathogen’s ability to reach the salivary glands and thus the transmission potential. The influence of DENV serotype and strain diversity on virus kinetics in the two main vector species, Aedes aegypti and Ae. albopictus, has been poorly characterized. We tested whether DENV replication kinetics vary systematically among serotypes and strains, using Australian strains of the two vectors.
Mosquitoes were blood fed with two strains per serotype, and sampled at 3, 6, 10 and 14-days post-exposure. Virus infection in mosquito bodies, and dissemination of virus to legs and wings, was detected using qRT-PCR. For both vectors, we found significant differences among serotypes in proportions of mosquitoes infected, with higher numbers for DENV-1 and -2 versus other serotypes.
Consistent with this, we observed that DENV-1 and -2 generally replicated to higher RNA levels than other serotypes, particularly at earlier time points. There were no significant differences in either speed of infection or dissemination between the mosquito species. Our results suggest that DENV diversity may have important epidemiological consequences by influencing virus kinetics in mosquito vectors.
A Plant Virus Ensures Viral Stability in the Hemolymph of Vector Insects through Suppressing Prophenoloxidase Activation
Most plant viruses require vector insects for transmission. Viral stability in the hemolymph of vector insects is a prerequisite for successful transmission of persistent plant viruses. However, knowledge of whether the proteolytic activation of prophenoloxidase (PPO) affects the stability of persistent plant viruses remains elusive.
Here, we explored the interplay between rice stripe virus (RSV) and the PPO cascade of the vector small brown planthopper. Phenoloxidase (PO) activity was suppressed by RSV by approximately 60%.
When the PPO cascade was activated, we found distinct melanization around RSV particles and serious damage to viral stability in the hemolymph. Viral suppression of PO activity was derived from obstruction of proteolytic cleavage of PPOs by binding of the viral nonstructural protein NS3. These results indicate that RSV attenuates the PPO response to ensure viral stability in the hemolymph of vector insects. Our research provides enlightening cues for controlling the transmission of vector-borne viruses.
IMPORTANCE Large ratios of vector-borne plant viruses circulate in the hemolymph of their vector insects before entering the salivary glands to be transmitted to plants. The stability of virions in the hemolymph is vital in this process. Activation of the proteolytic prophenoloxidase (PPO) to produce active phenoloxidase (PO) is one of the major innate immune pathways in insect hemolymph.
How a plant virus copes with the PPO immune reaction in its vector insect remains unclear. Here, we report that the PPO affects the stability of rice stripe virus (RSV), a notorious rice virus, in the hemolymph of a vector insect, the small brown planthopper. RSV suppresses PPO activation using viral nonstructural protein. Once the level of PO activity is elevated, RSV is melanized and eliminated from the hemolymph. Our work gives valuable clues for developing novel strategies for controlling the transmission of vector-borne plant viruses.